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    Rrp6 Rrp6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41798, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rrp6provided by FlyBase
    Official Full Name
    Rrp6provided by FlyBase
    Primary source
    FLYBASE:FBgn0038269
    Locus tag
    Dmel_CG7292
    See related
    AllianceGenome:FB:FBgn0038269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7292; Dmel\CG7292; DmRrp6; dRrp6; rrp6; RRP6
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity and single-stranded RNA binding activity. Involved in several processes, including chromosome segregation; defense response to virus; and nuclear RNA surveillance. Located in nuclear lamina and nucleolus. Part of nuclear exosome (RNase complex). Is expressed in organism. Orthologous to human EXOSC10 (exosome component 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rrp6 in Genome Data Viewer
    Location:
    88D6-88D6; 3-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14882498..14886246, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10708220..10711968, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene bitesize Neighboring gene long non-coding RNA:CR46024 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Drosophila melanogaster Dis3 ribonuclease. Mamolen M, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19800864, Free PMC Article
    2. Splice-site mutations cause Rrp6-mediated nuclear retention of the unspliced RNAs and transcriptional down-regulation of the splicing-defective genes. Eberle AB, et al. PLoS One, 2010 Jul 12. PMID 20634951, Free PMC Article
    3. RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination. Marin-Vicente C, et al. J Cell Sci, 2015 Mar 15. PMID 25632158
    4. The ribonuclease Dis3 is an essential regulator of the developmental transcriptome. Hou D, et al. BMC Genomics, 2012 Aug 1. PMID 22853036, Free PMC Article
    5. Rrp6 is recruited to transcribed genes and accompanies the spliced mRNA to the nuclear pore. Hessle V, et al. RNA, 2012 Aug. PMID 22745224, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that SU(VAR)3-9 targets RRP6 to a subset of heterochromatic loci where RRP6 degrades chromatin-associated non-coding RNAs in a process that is necessary to maintain the packaging of the heterochromatin
      Title: An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster.
    2. Genome-wide analysis reveals distinct substrate specificities of Rrp6 core exosome subunits.
      Title: Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits.
    3. dRrp6 has a core exosome-independent role in cell cycle and mitotic progression.
      Title: Core exosome-independent roles for Rrp6 in cell cycle progression.
    4. These results suggest that DmTRF4-1 (CG11265) and DmRrp6 are involved in the polyadenylation-mediated degradation of snRNAs in vivo.
      Title: TRF4 is involved in polyadenylation of snRNAs in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in histone mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear RNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent antisense transcript catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rrp6
    Names
    CG7292-PB
    CG7292-PC
    Rrp6-PB
    Rrp6-PC
    NP_001097795.1
    NP_001287330.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14882498..14886246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300401.1 → NP_001287330.1  Rrp6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287330.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3DN45, H9ZYN8, Q9VFF3
      Conserved Domains (5) summary
      cd06147
      Location:268 → 456
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:485 → 565
      HRDC; Helicase and RNase D C-terminal
      TIGR01388
      Location:273 → 622
      rnd; ribonuclease D
      pfam00985
      Location:735 → 833
      MSA_2; Merozoite Surface Antigen 2 (MSA-2) family
      pfam08066
      Location:55 → 125
      PMC2NT; PMC2NT (NUC016) domain

    2. NM_001104325.2 → NP_001097795.1  Rrp6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097795.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3DN45, H9ZYN8, Q9VFF3
      Conserved Domains (5) summary
      cd06147
      Location:268 → 456
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:485 → 565
      HRDC; Helicase and RNase D C-terminal
      TIGR01388
      Location:273 → 622
      rnd; ribonuclease D
      pfam00985
      Location:735 → 833
      MSA_2; Merozoite Surface Antigen 2 (MSA-2) family
      pfam08066
      Location:55 → 125
      PMC2NT; PMC2NT (NUC016) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFF3 Q9VFF3

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