Rpn8 Regulatory particle non-ATPase 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rpn8provided by FlyBase
Official Full Name: Regulatory particle non-ATPase 8provided by FlyBase
Primary source: FLYBASE:FBgn0002787
Locus tag: Dmel_CG3416
See related: AllianceGenome:FB:FBgn0002787
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3416; Dmel\CG3416; l(2)k08003; mov34; Mov34; P26270; p39B; PRSC_DROME; PSMD7; RPN8; S12
Summary: Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in dendrite. Part of proteasome regulatory particle. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study congenital heart disease; metabolic dysfunction-associated steatotic liver disease; and neurodegenerative disease. Orthologous to human PSMD7 (proteasome 26S subunit, non-ATPase 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24400028..24404527)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20287551..20292050)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables metal-dependent deubiquitinase activity	IKR Inferred from Key Residues more info
NOT enables metal-dependent deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables peptidase activity	IKR Inferred from Key Residues more info
NOT enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IMP Inferred from Mutant Phenotype more info	PubMed
part_of proteasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain