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    COX6B Cytochrome c oxidase subunit 6B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32989, updated on 17-Dec-2024

    Summary

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    Official Symbol
    COX6Bprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 6Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031066
    Locus tag
    Dmel_CG14235
    See related
    AllianceGenome:FB:FBgn0031066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CcoVIb; CG14235; CoVIb; Cox6b; COXG; Dmel\CG14235; Q8IQW2; vib; VIb
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to several human genes including COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX6B in Genome Data Viewer
    Location:
    18E5-18E5; 1-64 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19740537..19744335, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19634570..19638368, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Adaptor Protein complex 1/2, beta subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45501 Neighboring gene Ribonuclease P protein subunit p20 Neighboring gene parvin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
    2. Apple polyphenols extend the mean lifespan of Drosophila melanogaster. Peng C, et al. J Agric Food Chem, 2011 Mar 9. PMID 21319854
    3. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Kemppainen KK, et al. Hum Mol Genet, 2014 Apr 15. PMID 24293544, Free PMC Article
    4. The misregulation of mitochondria-associated genes caused by GAGA-factor lack promotes autophagic germ cell death in Drosophila testes. Dorogova NV, et al. Genetica, 2023 Dec. PMID 37819589
    5. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Porcelli D, et al. Mitochondrion, 2010 Aug. PMID 20388558

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 6B
    Names
    CG14235-PA
    CG14235-PB
    CG14235-PC
    CG14235-PD
    COX6B-PA
    COX6B-PB
    COX6B-PC
    COX6B-PD
    cytochrome c oxidase VIb
    cytochrome c oxidase polypeptide VIb
    cytochrome c oxidase subunit VIb
    cytochrome c oxidase subunitVIb
    subunit VIb

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19740537..19744335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167680.3 → NP_728296.1  cytochrome c oxidase subunit 6B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQW2
      Related
      FBpp0074585
      Conserved Domains (1) summary
      cd00926
      Location:3 → 76
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_167678.3 → NP_728294.1  cytochrome c oxidase subunit 6B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728294.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWD1
      Related
      FBpp0074584
      Conserved Domains (1) summary
      cd00926
      Location:22 → 95
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    3. NM_001258838.2 → NP_001245767.1  cytochrome c oxidase subunit 6B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQW2
      Conserved Domains (1) summary
      cd00926
      Location:3 → 76
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    4. NM_167679.3 → NP_728295.1  cytochrome c oxidase subunit 6B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQW2
      Related
      FBpp0074586
      Conserved Domains (1) summary
      cd00926
      Location:3 → 76
      Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQW2 Q8IQW2
    Q9VWD1 Q9VWD1

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