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    Pex7 Peroxin 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38994, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pex7provided by FlyBase
    Official Full Name
    Peroxin 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0035922
    Locus tag
    Dmel_CG6486
    See related
    AllianceGenome:FB:FBgn0035922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6486; DmelPex7; Dmel\CG6486; PEX&; PEX7
    Summary
    Predicted to enable peroxisome matrix targeting signal-2 binding activity. Involved in protein import into peroxisome matrix. Located in cytosol and peroxisome. Is expressed in embryonic cortex; organism; supraesophageal ganglion; ventral nerve cord; and yolk. Used to study Peroxisome biogenesis disorder 9B. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 9B and rhizomelic chondrodysplasia punctata type 1. Orthologous to human PEX7 (peroxisomal biogenesis factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pex7 in Genome Data Viewer
    Location:
    66D9-66D10; 3-26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8647145..8651011)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8640245..8644111)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 66D Neighboring gene uncharacterized protein Neighboring gene Arrestin 2 Neighboring gene hairy Neighboring gene long non-coding RNA:CR44526

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peroxisome matrix targeting signal-2 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peroxisome matrix targeting signal-2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in peroxisome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into peroxisome matrix IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxin 7
    Names
    CG6486-PA
    CG6486-PB
    Pex7-PA
    Pex7-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8647145..8651011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139994.2NP_648251.1  peroxin 7, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4T3, Q9VSN7
      Related
      FBpp0076295
      Conserved Domains (3) summary
      COG2319
      Location:85328
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:74121
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:53328
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001144442.1NP_001137914.1  peroxin 7, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4T3, Q9VSN7
      Conserved Domains (3) summary
      COG2319
      Location:85328
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:74121
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:53328
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...