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    Ca-Ma2d Ca[2+] channel Muscle-specific alpha2/delta subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34951, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ca-Ma2dprovided by FlyBase
    Official Full Name
    Ca[2+] channel Muscle-specific alpha2/delta subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261999
    Locus tag
    Dmel_CG42817
    See related
    AllianceGenome:FB:FBgn0261999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha2delta-3; BG:DS07473.1; CG12455; CG42817; Dmel\CG42817; DS07473.1A; Ma2/d
    Old locus tag
    Dmel_CG12455
    Summary
    Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Located in T-tubule and sarcoplasmic reticulum. Is expressed in adult head; adult heart; larval muscle system; and spermatozoon. Human ortholog(s) of this gene implicated in retinal cone dystrophy 4. Orthologous to human CACNA2D4 (calcium voltage-gated channel auxiliary subunit alpha2delta 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Ca-Ma2d in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16231475..16241527)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16231475..16241527)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43840 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PRL-1 phosphatase

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Ca[2+] channel Muscle-specific alpha2/delta subunit
    Names
    CG42817-PA
    CG42817-PB
    Ca-Ma2d-PA
    Ca-Ma2d-PB
    Muscle-specific alpha2/delta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16231475..16241527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273557.2NP_001260486.1  Ca[2+] channel Muscle-specific alpha2/delta subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260486.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BIB2, Q8IP22
      Conserved Domains (3) summary
      cd01463
      Location:267461
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:510587
      Cache_1; Cache domain
      pfam08399
      Location:124251
      VWA_N; VWA N-terminal
    2. NM_165149.3NP_723955.2  Ca[2+] channel Muscle-specific alpha2/delta subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723955.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BIB2, Q8IP22
      Conserved Domains (3) summary
      cd01463
      Location:267461
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:510587
      Cache_1; Cache domain
      pfam08399
      Location:124251
      VWA_N; VWA N-terminal