Fkbp12 FK506-binding protein 12kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fkbp12provided by FlyBase
Official Full Name: FK506-binding protein 12kDprovided by FlyBase
Primary source: FLYBASE:FBgn0013954
Locus tag: Dmel_CG11001
See related: AllianceGenome:FB:FBgn0013954
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 11001; 143729_at; CG11001; dFKBP12; Dmel\CG11001; DrFKBP12; Fk506-bp2; FK506-bp2; FK506-BP2; fkbp; FKBP; FKBP12
Summary: Enables type I transforming growth factor beta receptor binding activity. Located in plasma membrane. Is expressed in several structures, including adult head; female germline cell; ganglia; gut section; and somatic muscle cell. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19290109..19290962)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15177614..15178467)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables type I transforming growth factor beta receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	HDA more info	PubMed
is_active_in sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG11001-PA; DmFKBP12; FK506-binding protein; FK506-binding protein 2; Fkbp12-PA; calstabin

NP_523792.2

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The following sections contain reference sequences that belong to a specific genome build. Explain