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    cyp33 cyclophilin-33 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp33provided by FlyBase
    Official Full Name
    cyclophilin-33provided by FlyBase
    Primary source
    FLYBASE:FBgn0028382
    Locus tag
    Dmel_CG4886
    See related
    AllianceGenome:FB:FBgn0028382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4886; Cyp33; CYP33; Dcyp33; Dmel\CG4886
    Summary
    Predicted to enable cyclosporin A binding activity; mRNA binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Part of Prp19 complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; ganglia; and mesoderm. Orthologous to human PPIE (peptidylprolyl isomerase E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cyp33 in Genome Data Viewer
    Location:
    54C3-54C3; 2-83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17545222..17546400)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13432727..13433905)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit b Neighboring gene Coiled-coil and C2 domain containing 2A Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L18A Neighboring gene Misexpression suppressor of ras 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. Hom RA, et al. J Mol Biol, 2010 Jul 9. PMID 20460131, Free PMC Article
    2. Conservation of gene order, structure and sequence between three closely linked genes in Drosophila melanogaster and Drosophila virilis. Lyamouri M, et al. Gene, 2002 Jan 9. PMID 11814692
    3. A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells. Anderson M, et al. Dev Genes Evol, 2002 Apr. PMID 11976948
    4. Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3. Chauhan C, et al. Development, 2012 Jun. PMID 22569554, Free PMC Article
    5. Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. Guilgur LG, et al. Elife, 2014 Apr 22. PMID 24755291, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells.
      Title: A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    cyclophilin-33
    Names
    CG4886-PA
    cyp33-PA
    NP_523773.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17545222..17546400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079049.4 → NP_523773.1  cyclophilin-33 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3G3
      Related
      FBpp0086101
      Conserved Domains (2) summary
      cd01926
      Location:139 → 297
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd12347
      Location:8 → 80
      RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3G3.1 Q9V3G3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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