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    Cyp4c3 Cytochrome P450 4c3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4c3provided by FlyBase
    Official Full Name
    Cytochrome P450 4c3provided by FlyBase
    Primary source
    FLYBASE:FBgn0015032
    Locus tag
    Dmel_CG1438
    See related
    AllianceGenome:FB:FBgn0015032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4C3; CG1438; cyp4c3; Dmel\CG1438; P-450; P450
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in embryonic/larval hindgut; embryonic/larval salivary gland; embryonic/larval tracheal section; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4c3 in Genome Data Viewer
    Location:
    100A7-100A7; 3-101 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30894038..30900688)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26719760..26726410)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Saposin-related Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46220

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Maïbèche-Coisne M, et al. Biochem Biophys Res Commun, 2000 Jul 14. PMID 10891384
    2. Drosophila Fed ARA and EPA Yields Eicosanoids, 15S-Hydroxy-5Z,8Z, 11Z, 13E-Eicosatetraenoic Acid, and 15S-Hydroxy-5Z,8Z,11Z,13E,17Z-Eicosapentaenoic Acid. Tan L, et al. Lipids, 2016 Apr. PMID 26931457
    3. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871
    4. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Keogh DP, et al. Experientia, 1992 Jan 15. PMID 1737575
    5. Alkaloid metabolism by cytochrome P-450 enzymes in Drosophila melanogaster. Danielson PB, et al. Comp Biochem Physiol B Biochem Mol Biol, 1995 Apr. PMID 7749620

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4c3
    Names
    CG1438-PA
    Cyp4c3-PA
    cytochrome P450
    cytochrome P450-4c3
    NP_524598.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30894038..30900688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079859.4 → NP_524598.1  cytochrome P450 4c3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524598.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24121, Q9VA27
      Related
      FBpp0085074
      Conserved Domains (1) summary
      pfam00067
      Location:59 → 531
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA27.1 Q9VA27

    Gene LinkOut

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