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    CAH1 Carbonic anhydrase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAH1provided by FlyBase
    Official Full Name
    Carbonic anhydrase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027844
    Locus tag
    Dmel_CG7820
    See related
    AllianceGenome:FB:FBgn0027844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00941.1; CAH; CG7820; Dmel\CG7820; Gh7
    Summary
    Enables carbonate dehydratase activity. Involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult fat body; adult head; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to several human genes including CA13 (carbonic anhydrase 13); CA2 (carbonic anhydrase 2); and CA5A (carbonic anhydrase 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CAH1 in Genome Data Viewer
    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13803626..13809994)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13803626..13809994)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Secretory 71 Neighboring gene Adenosine deaminase, tRNA-specific 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Son of sevenless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families. Hewett-Emmett D, et al. Mol Phylogenet Evol, 1996 Feb. PMID 8673298
    2. Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster. Syrjänen L, et al. Bioorg Med Chem, 2013 Mar 15. PMID 22989910
    3. Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen. Helenius IT, et al. J Immunol, 2016 Jan 15. PMID 26643480, Free PMC Article
    4. Genes associated with honey bee behavioral maturation affect clock-dependent and -independent aspects of daily rhythmic activity in fruit flies. Fu C, et al. PLoS One, 2012. PMID 22606218, Free PMC Article
    5. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbonic anhydrase 1
    Names
    CAH1-PA
    CG7820-PA
    NP_523561.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13803626..13809994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078837.4 → NP_523561.1  carbonic anhydrase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523561.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V396
      Related
      FBpp0080116
      Conserved Domains (1) summary
      smart01057
      Location:5 → 263
      Carb_anhydrase; Eukaryotic-type carbonic anhydrase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V396 Q9V396

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