Orc3 Origin recognition complex subunit 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Orc3provided by FlyBase
Official Full Name: Origin recognition complex subunit 3provided by FlyBase
Primary source: FLYBASE:FBgn0005654
Locus tag: Dmel_CG4088
See related: AllianceGenome:FB:FBgn0005654
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4088; Dmel\CG4088; DmOrc3; DmORC3; l(2)49Fd; l(2)vr6; lat; Lat; LAT; latheo; ORC; orc3; ORC3; vr-6; vr6
Summary: Enables ribonucleoprotein complex binding activity. Involved in DNA replication initiation and positive regulation of border follicle cell migration. Located in nucleus. Part of nuclear origin of replication recognition complex and nuclear pore. Is expressed in adult brain; bouton; centripetal follicle cell; egg chamber; and neuromuscular junction. Orthologous to human ORC3 (origin recognition complex subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13202728..13206547, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9090233..9094052, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Study of the Interaction between Xmas-2, the Main Protein of TREX-2 mRNA Export Complex, and the Orc3 Protein, a Subunit of ORC Complex of D. melanogaster.
Title: Study of the Interaction between Xmas-2, the Main Protein of TREX-2 mRNA Export Complex, and the Orc3 Protein, a Subunit of ORC Complex of D. melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	NAS Non-traceable Author Statement more info	PubMed
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in larval feeding behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in learning	NAS Non-traceable Author Statement more info	PubMed
involved_in learning or memory	NAS Non-traceable Author Statement more info	PubMed
involved_in olfactory learning	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA replication preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear origin of replication recognition complex	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pre-replicative complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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