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    Phax Phosphorylated adaptor for RNA export [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phaxprovided by FlyBase
    Official Full Name
    Phosphorylated adaptor for RNA exportprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033380
    Locus tag
    Dmel_CG8069
    See related
    AllianceGenome:FB:FBgn0033380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH22533; CG8069; Dmel\CG8069; dPHAX
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in snRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human PHAX (phosphorylated adaptor for RNA export). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Phax in Genome Data Viewer
    Location:
    45A8-45A8; 2-60 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9114274..9116030)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5001779..5003535)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphoglucomutase 2a Neighboring gene Mystery 45A Neighboring gene tsunagi Neighboring gene Suppressor of variegation 2-10 Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Allele-specific alternative splicing of Drosophila Ribosomal protein S21 suppresses a lethal mutation in the Phosphorylated adaptor for RNA export (Phax) gene. Garcia EL. G3 (Bethesda), 2022 Aug 25. PMID 35920767, Free PMC Article
    2. Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy. Garcia EL, et al. RNA, 2016 Aug. PMID 27268418, Free PMC Article
    3. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
    4. A genetic screen to uncover mechanisms underlying lipid transfer protein function at membrane contact sites. Mishra S, et al. Life Sci Alliance, 2024 Jun. PMID 38499328, Free PMC Article
    5. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Huang C, et al. Genes Dev, 2018 May 1. PMID 29773557, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylated adaptor for RNA export
    Names
    CG8069-PA
    CG8069-PB
    PHosphorylated adaptor for RNA export
    Phax-PA
    Phax-PB
    similar to PHAX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9114274..9116030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165644.3 → NP_724748.1  phosphorylated adaptor for RNA export, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL95
      Related
      FBpp0100001
      Conserved Domains (1) summary
      pfam10258
      Location:147 → 230
      RNA_GG_bind; PHAX RNA-binding domain

    2. NM_136612.4 → NP_610456.4  phosphorylated adaptor for RNA export, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610456.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7P3, Q8SYG4, Q9V537
      Conserved Domains (1) summary
      pfam10258
      Location:243 → 326
      RNA_GG_bind; PHAX RNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7P3 A1Z7P3
    Q6NL95 Q6NL95
    Q8SYG4 Q8SYG4

    Gene LinkOut

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