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    Rift Riboflavin transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Riftprovided by FlyBase
    Official Full Name
    Riboflavin transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039882
    Locus tag
    Dmel_CG11576
    See related
    AllianceGenome:FB:FBgn0039882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg11576; CG11576; Dmel\CG11576; drift
    Summary
    Predicted to enable riboflavin transmembrane transporter activity. Involved in riboflavin transport. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; amnioserosa; embryonic/larval crystal cell; embryonic/larval midgut; and embryonic/larval midgut primordium. Used to study Brown-Vialetto-Van Laere syndrome. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; Fazio-Londe disease; and riboflavin deficiency. Orthologous to several human genes including SLC52A3 (solute carrier family 52 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rift in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31806867..31810186, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27632589..27635908, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 100a Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 100F Neighboring gene Ferrochelatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clinical, pathological and functional characterization of riboflavin-responsive neuropathy. Manole A, et al. Brain, 2017 Nov 1. PMID 29053833, Free PMC Article
    2. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article
    3. A genetic toolkit for tagging intronic MiMIC containing genes. Nagarkar-Jaiswal S, et al. Elife, 2015 Jun 23. PMID 26102525, Free PMC Article
    4. RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides. Abruzzi KC, et al. PLoS Genet, 2017 Feb. PMID 28182648, Free PMC Article
    5. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Kumar S, et al. Sci Rep, 2016 Nov 7. PMID 27819340, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables riboflavin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in riboflavin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    riboflavin transporter
    Names
    CG11576-PA
    Rift-PA
    drosophila riboflavin transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31806867..31810186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143644.3 → NP_651901.3  riboflavin transporter [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651901.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9S9
      Related
      FBpp0085211
      Conserved Domains (1) summary
      pfam06237
      Location:320 → 418
      DUF1011; Protein of unknown function (DUF1011)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYL6 Q8SYL6
    Q9V9S9 Q9V9S9

    Gene LinkOut

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