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    mEFTu1 mitochondrial translation elongation factor Tu 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mEFTu1provided by FlyBase
    Official Full Name
    mitochondrial translation elongation factor Tu 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024556
    Locus tag
    Dmel_CG6050
    See related
    AllianceGenome:FB:FBgn0024556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6050; Dmel\CG6050; dTUFm; EF-Tu1; eftu-M; efTuM; EfTuM; l(3)L4569; mtEF-Tu; TUFm
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Located in mitochondrion. Is expressed in adult head and adult heart. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See mEFTu1 in Genome Data Viewer
    Location:
    50A14-50A14; 2-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13507557..13509332)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9395062..9396837)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene bb in a boxcar Neighboring gene downstream of receptor kinase Neighboring gene mars Neighboring gene Myb-interacting protein 120 Neighboring gene Vesicular monoamine transporter Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Duplication of Drosophila melanogaster mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues. Sato A, et al. Biochem J, 2017 Mar 7. PMID 28130490
    2. Paradoxical Mitophagy Regulation by PINK1 and TUFm. Lin J, et al. Mol Cell, 2020 Nov 19. PMID 33113344
    3. Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development. Zhou J, et al. PLoS Genet, 2019 Sep. PMID 31553718, Free PMC Article
    4. Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Lewis PW, et al. Mol Cell Biol, 2012 Aug. PMID 22688510, Free PMC Article
    5. Mars, a Drosophila protein related to vertebrate HURP, is required for the attachment of centrosomes to the mitotic spindle during syncytial nuclear divisions. Zhang G, et al. J Cell Sci, 2009 Feb 15. PMID 19174464

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila melanogaster mitochondrial EF-Tu has two isoforms.
      Title: Duplication of Drosophila melanogaster mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial translation elongation factor Tu 1
    Names
    CG6050-PA
    CG6050-PB
    elongation factor Tu mitochondrial
    mEFTu1-PA
    mEFTu1-PB
    translation elongation factor Tu

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13507557..13509332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169673.2 → NP_001163144.1  mitochondrial translation elongation factor Tu 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9E3, Q86NS6
      Conserved Domains (4) summary
      cd01884
      Location:81 → 274
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      PRK00049
      Location:73 → 463
      PRK00049; elongation factor Tu; Reviewed
      cd03697
      Location:282 → 368
      EFTU_II; Domain II of elongation factor Tu
      cd03706
      Location:371 → 462
      mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)

    2. NM_080013.4 → NP_524752.1  mitochondrial translation elongation factor Tu 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9E3, Q86NS6
      Related
      FBpp0086790
      Conserved Domains (4) summary
      cd01884
      Location:81 → 274
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      PRK00049
      Location:73 → 463
      PRK00049; elongation factor Tu; Reviewed
      cd03697
      Location:282 → 368
      EFTU_II; Domain II of elongation factor Tu
      cd03706
      Location:371 → 462
      mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9E3 A1Z9E3
    Q95TV3 Q95TV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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