GEFmeso Guanine nucleotide exchange factor in mesoderm [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GEFmesoprovided by FlyBase
Official Full Name: Guanine nucleotide exchange factor in mesodermprovided by FlyBase
Primary source: FLYBASE:FBgn0050115
Locus tag: Dmel_CG30115
See related: AllianceGenome:FB:FBgn0050115
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18430; CG30115; CG5503; Dmel\CG30115
Summary: Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in imaginal disc-derived appendage morphogenesis; positive regulation of stem cell proliferation; and regulation of signal transduction. Is expressed in several structures, including anterior endoderm; dorsal vessel primordium; embryonic/larval midgut primordium; imaginal disc; and somatic trunk mesoderm derivative. Orthologous to several human genes including PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18554119..18611777, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14441624..14499282, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Cdc42 protein signal transduction	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

Names: CG30115-PE; CG30115-PF; CG30115-PG; GEFmeso-PE; GEFmeso-PF; GEFmeso-PG

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The following sections contain reference sequences that belong to a specific genome build. Explain