ADD1 ADD domain-containing protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ADD1provided by FlyBase
Official Full Name: ADD domain-containing protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0026573
Locus tag: Dmel_CG8290
See related: AllianceGenome:FB:FBgn0026573
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:LD29214; CG8290; dadd1; dAdd1; dADD1; Dmel\CG8290; LD29214
Summary: Enables chromatin DNA binding activity and methylated histone binding activity. Involved in regulatory ncRNA-mediated heterochromatin formation. Located in pericentric heterochromatin and polytene chromosome. Is expressed in several structures, including antennal anlage; central brain anlage; central brain primordium; dorsal head epidermis anlage; and ganglia. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11970686..11977721)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7858191..7865226)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Multiple Roles of dXNP and dADD1-Drosophila Orthologs of ATRX Chromatin Remodeler.
Title: Multiple Roles of dXNP and dADD1-Drosophila Orthologs of ATRX Chromatin Remodeler.
dadd1-encoded proteins participate with dAtrx in some cellular functions such as heterochromatin maintenance
Title: Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome band	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain