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    fest wurstfest [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    festprovided by FlyBase
    Official Full Name
    wurstfestprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034435
    Locus tag
    Dmel_CG9975
    See related
    AllianceGenome:FB:FBgn0034435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9975; Dmel\CG9975
    Summary
    Involved in negative regulation of translation. Located in cytosol. Part of translation repressor complex. Is expressed in several structures, including adult head; spermatocyte; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fest in Genome Data Viewer
    Location:
    56D1-56D1; 2-89 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19341809..19345754)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15229314..15233259)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Endophilin B Neighboring gene Rad, Gem/Kir family member 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell type-specific translational repression of Cyclin B during meiosis in males. Baker CC, et al. Development, 2015 Oct 1. PMID 26443637, Free PMC Article
    2. Cell-type-specific interacting proteins collaborate to regulate the timing of Cyclin B protein expression in male meiotic prophase. Baker CC, et al. Development, 2023 Nov 15. PMID 37882771, Free PMC Article
    3. Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells. Cash AC, et al. BMC Dev Biol, 2012 Jan 17. PMID 22252300, Free PMC Article
    4. The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila. Lu C, et al. Development, 2013 Sep. PMID 23884444, Free PMC Article
    5. Dynamic sex chromosome expression in Drosophila male germ cells. Mahadevaraju S, et al. Nat Commun, 2021 Feb 9. PMID 33563972, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fest is a cell type-specific repressor of cycB translation during meiotic prophase in growing spermatocytes.
      Title: Cell type-specific translational repression of Cyclin B during meiosis in males.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    part_of translation repressor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wurstfest
    Names
    CG9975-PA
    CG9975-PB
    fest-PA
    fest-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19341809..19345754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137568.3 → NP_611412.1  wurstfest, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBJ8, Q8IHB1
      Related
      FBpp0085706

    2. NM_001202047.2 → NP_001188976.1  wurstfest, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188976.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCT9, Q8IHB1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCT9 A0A0B4JCT9
    A1ZBJ8 A1ZBJ8
    Q8IHB1 Q8IHB1

    Gene LinkOut

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