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    SmydA-4 SET and MYND domain containing, arthropod-specific, member 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SmydA-4provided by FlyBase
    Official Full Name
    SET and MYND domain containing, arthropod-specific, member 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0030257
    Locus tag
    Dmel_CG11160
    See related
    AllianceGenome:FB:FBgn0030257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11160; Dmel\CG11160
    Summary
    Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SmydA-4 in Genome Data Viewer
    Location:
    10A3-10A3; 1-33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11044756..11049540)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10938789..10943573)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Myosin 10A Neighboring gene C901 Neighboring gene vexed Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fine mapping of dominant X-linked incompatibility alleles in Drosophila hybrids. Matute DR, et al. PLoS Genet, 2014 Apr. PMID 24743238, Free PMC Article
    2. PAPI, a novel TUDOR-domain protein, complexes with AGO3, ME31B and TRAL in the nuage to silence transposition. Liu L, et al. Development, 2011 May. PMID 21447556, Free PMC Article
    3. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
    4. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
    5. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone deacetylase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SET and MYND domain containing, arthropod-specific, member 4
    Names
    CG11160-PA
    CG11160-PB
    CG11160-PC
    SmydA-4-PA
    SmydA-4-PB
    SmydA-4-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11044756..11049540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272507.2 → NP_001259436.1  SET and MYND domain containing, arthropod-specific, member 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHK0

    2. NM_167262.3 → NP_727478.1  SET and MYND domain containing, arthropod-specific, member 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR97, Q8SWU5
      Related
      FBpp0073247

    3. NM_132447.3 → NP_572675.1  SET and MYND domain containing, arthropod-specific, member 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ41
      Related
      FBpp0073246
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHK0 M9PHK0
    Q8IR97 Q8IR97
    Q8SWU5 Q8SWU5
    Q9VZ41 Q9VZ41

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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