sisA sisterless A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sisAprovided by FlyBase
Official Full Name: sisterless Aprovided by FlyBase
Primary source: FLYBASE:FBgn0003411
Locus tag: Dmel_CG1641
See related: AllianceGenome:FB:FBgn0003411
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1641; DM29; Dmel\CG1641; sis a; sis A; sis-a; sis-A; sisa
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including midgut development; positive regulation of transcription by RNA polymerase II; and primary sex determination. Predicted to be located in nucleus. Is expressed in cleavage nucleus; organism; yolk; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11321579..11322357, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11215612..11216390, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sex determination	TAS Traceable Author Statement more info	PubMed
involved_in sex determination, establishment of X:A ratio	NAS Non-traceable Author Statement more info	PubMed
involved_in sex determination, establishment of X:A ratio	TAS Traceable Author Statement more info	PubMed