U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    subdued subdued [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42340, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    subduedprovided by FlyBase
    Official Full Name
    subduedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038721
    Locus tag
    Dmel_CG16718
    See related
    AllianceGenome:FB:FBgn0038721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16718; Dmel\CG16718; Subdued
    Summary
    Enables monoatomic ion channel activity and phospholipid scramblase activity. Involved in several processes, including chloride transport; defense response to Gram-negative bacterium; and detection of temperature stimulus involved in sensory perception. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult proventriculus; central nervous system; epithelial tube; and larval multidendritic neurons. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to several human genes including ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See subdued in Genome Data Viewer
    Location:
    92A11-92A11; 3-66 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19633418..19642722, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15459140..15468444, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-9373 stem loop Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 13kD subunit Neighboring gene Nucleoporin 58kD

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila bestrophin-1 currents are regulated by phosphorylation via a CaMKII dependent mechanism. Duran C, et al. PLoS One, 2013. PMID 23554946, Free PMC Article
    2. Subdued, a TMEM16 family Ca²⁺-activated Cl⁻channel in Drosophila melanogaster with an unexpected role in host defense. Wong XM, et al. Elife, 2013 Nov 5. PMID 24192034, Free PMC Article
    3. Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids. Le T, et al. J Biol Chem, 2019 Mar 22. PMID 30700552, Free PMC Article
    4. The anoctamin family channel subdued mediates thermal nociception in Drosophila. Jang W, et al. J Biol Chem, 2015 Jan 23. PMID 25505177, Free PMC Article
    5. Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila. Himmel NJ, et al. Elife, 2023 Jan 23. PMID 36688373, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly calcium-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly calcium-gated chloride channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of cold stimulus involved in thermoception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in plasma membrane phospholipid scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    subdued
    Names
    CG16718-PA
    CG16718-PB
    CG16718-PD
    CG16718-PE
    CG16718-PF
    subdued-PA
    subdued-PB
    subdued-PD
    subdued-PE
    subdued-PF

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19633418..19642722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142563.2 → NP_650820.1  subdued, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P24, Q9VDV4
      Related
      FBpp0083215
      Conserved Domains (2) summary
      pfam04547
      Location:407 → 983
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:186 → 404
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. NM_001202319.2 → NP_001189248.1  subdued, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189248.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCY1, Q86P24
      Conserved Domains (2) summary
      pfam04547
      Location:431 → 1007
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:186 → 428
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    3. NM_169867.3 → NP_732439.1  subdued, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732439.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P24, Q8IN71
      Related
      FBpp0083216
      Conserved Domains (2) summary
      pfam04547
      Location:258 → 834
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:37 → 255
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    4. NM_001275808.1 → NP_001262737.1  subdued, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGH4, Q86P24
      Conserved Domains (2) summary
      pfam04547
      Location:282 → 858
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:37 → 279
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    5. NM_001275807.1 → NP_001262736.1  subdued, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262736.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P24, Q8IN71
      Conserved Domains (2) summary
      pfam04547
      Location:258 → 834
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:37 → 255
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCY1 A0A0B4JCY1
    A0A0B4KGH4 A0A0B4KGH4
    Q86P24 Q86P24
    Q8IN71 Q8IN71
    Q9VDV4 Q9VDV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous