Myc Myc [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mycprovided by FlyBase
Official Full Name: Mycprovided by FlyBase
Primary source: FLYBASE:FBgn0262656
Locus tag: Dmel_CG10798
See related: AllianceGenome:FB:FBgn0262656
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.171; bHLHe57; c-myc; c-Myc; c-MYC; CG10798; cMyc; d-myc; D-Myc; Diminutive; dm; Dm; DM; dm/dMyc; dm/myc; Dmel\CG10798; dmyc; dMyc; dMYC; Dmyc; DMYc; dmyc1; dMyc1; EG:BACN5I9.1; l(1)G0139; l(1)G0354; l(1)G0359; myc; MYC
Summary: Enables DNA binding activity; DNA-binding transcription factor activity; and ubiquitin-specific protease binding activity. Involved in several processes, including DNA endoreduplication; positive regulation of developmental growth; and positive regulation of macromolecule biosynthetic process. Located in nucleolus. Part of protein-containing complex. Colocalizes with histone locus body. Is expressed in several structures, including anlage in statu nascendi; cuboidal/columnar epithelium; embryonic/larval midgut primordium; germline cell; and gut section. Used to study brain cancer and cancer. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3D2-3D2; 1-3 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (3373159..3391697)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3267192..3285730)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila tumor necrosis factor Eiger promotes Myc supercompetition independent of canonical Jun N-terminal kinase signaling.
Title: The Drosophila tumor necrosis factor Eiger promotes Myc supercompetition independent of canonical Jun N-terminal kinase signaling.
Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila.
Title: Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila.
Myc plays an important role in Drosophila P-M hybrid dysgenesis to eliminate germline cells with genetic damage.
Title: Myc plays an important role in Drosophila P-M hybrid dysgenesis to eliminate germline cells with genetic damage.
Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability.
Title: Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability.
Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila.
Title: Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila.
Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
Title: Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.
UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis.
Title: UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis.
Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2.
Title: Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2.
Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism.
Title: Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism.
The transcription factor Myc acts downstream of Fzr during endoreplication in Drosophila salivary gland.
Title: A novel transcriptional cascade is involved in Fzr-mediated endoreplication.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-specific protease binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleologenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of rRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with histone locus body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: Myc

Names: CG10798-PA; CG10798-PB; Myc-PA; Myc-PB; diminuitive; diminutive; lethal (1) G0354; lethal (1) G0359

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

3373159..3391697

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272275.1 → NP_001259204.1 Myc, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259204.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O96903, P91665, Q9W4S7

UniProtKB/TrEMBL

M9PGK0

Conserved Domains (1) summary

cd00083
Location:625 → 682

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_080323.4 → NP_525062.2 Myc, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525062.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O96903, P91665, Q9W4S7

UniProtKB/TrEMBL

M9PGK0

Related

FBpp0070501

Conserved Domains (1) summary

cd00083
Location:625 → 682

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...