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    PolrMT RNA polymerase mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolrMTprovided by FlyBase
    Official Full Name
    RNA polymerase mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261938
    Locus tag
    Dmel_CG4644
    See related
    AllianceGenome:FB:FBgn0261938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4644; Dmel\CG4644; mt RNA pol; mtRNA-pol; mtRNAP; mtRNApol; mtRNAPol; POLRMT; RPO41
    Summary
    Enables 3'-5'-RNA exonuclease activity and DNA primase activity. Involved in DNA replication, synthesis of primer and DNA synthesis involved in mitochondrial DNA replication. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial DNA-directed RNA polymerase complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 55. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolrMT in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1103254..1108373, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1103254..1108373, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene asteroid Neighboring gene Autophagy-related 4a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial transcription termination factor DmTTF. Fernández-Moreno MA, et al. Biochem J, 2009 Mar 1. PMID 19032147
    2. The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster. Liu Y, et al. Nat Cell Biol, 2022 May. PMID 35449456
    3. Modulation of mitochondrial nucleoid structure during aging and by mtDNA content in Drosophila. Wang LJ, et al. Biol Open, 2021 Jun 15. PMID 34180963, Free PMC Article
    4. Identification and characterization of genes required for compensatory growth in Drosophila. Gerhold AR, et al. Genetics, 2011 Dec. PMID 21926302, Free PMC Article
    5. The initiation of mitochondrial DNA replication. Liu Y, et al. Biochem Soc Trans, 2024 Jun 26. PMID 38884788, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA primase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mitochondrial promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitochondrial single subunit type RNA polymerase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication, synthesis of primer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA synthesis involved in mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial DNA-directed RNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase mitochondrial
    Names
    CG4644-PA
    CG4644-PB
    PolrMT-PA
    PolrMT-PB
    mitochondrial RNA polymerase
    NP_001259853.1
    NP_608565.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1103254..1108373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272924.1 → NP_001259853.1  RNA polymerase mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPW4
      Conserved Domains (5) summary
      COG5108
      Location:286 → 1369
      RPO41; Mitochondrial DNA-directed RNA polymerase [Transcription]
      sd00004
      Location:314 → 342
      PPR; PPR repeat [structural motif]
      pfam00940
      Location:962 → 1368
      RNA_pol; DNA-dependent RNA polymerase
      pfam01535
      Location:358 → 386
      PPR; PPR repeat
      pfam14700
      Location:513 → 829
      RPOL_N; DNA-directed RNA polymerase N-terminal

    2. NM_134721.3 → NP_608565.1  RNA polymerase mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPW4
      Related
      FBpp0077654
      Conserved Domains (5) summary
      COG5108
      Location:286 → 1369
      RPO41; Mitochondrial DNA-directed RNA polymerase [Transcription]
      sd00004
      Location:314 → 342
      PPR; PPR repeat [structural motif]
      pfam00940
      Location:962 → 1368
      RNA_pol; DNA-dependent RNA polymerase
      pfam01535
      Location:358 → 386
      PPR; PPR repeat
      pfam14700
      Location:513 → 829
      RPOL_N; DNA-directed RNA polymerase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRK5 Q8MRK5
    Q9VPW4 Q9VPW4

    Gene LinkOut

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