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    AOX1 Aldehyde oxidase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41894, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AOX1provided by FlyBase
    Official Full Name
    Aldehyde oxidase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0267408
    Locus tag
    Dmel_CG18522
    See related
    AllianceGenome:FB:FBgn0267408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18522; CT42272; DmAO1; Dmel\CG18522; lpo; LPO; Po; PO
    Summary
    Enables pyridoxal oxidase activity. Involved in pyridoxal metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic ventral epidermis; embryonic/larval midgut; and epithelium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AOX1 in Genome Data Viewer
    Location:
    88F7-88F7; 3-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15532137..15537292, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11357859..11363014, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aldehyde oxidase 2 Neighboring gene Aldehyde oxidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A third locus (ipo) affecting pyridoxal oxidase in Drosophila melanogaster. Collins JF, et al. Genetics, 1969 Apr. PMID 5364965, Free PMC Article
    2. Gene regulation in Drosophila: independent expression of closely linked, related structural loci. Dickinson WJ, et al. Biochem Genet, 1976 Oct. PMID 827284
    3. Tissue-specific and substrate-specific detection of aldehyde and pyridoxal oxidase in larval and imaginal tissues of Drosophila melanogaster. Cypher JJ, et al. Biochem Genet, 1982 Apr. PMID 6808989
    4. Molybdenum hydroxylases in Drosophila. II. Molybdenum cofactor in xanthine dehydrogenase, aldehyde oxidase and pyridoxal oxidase. Warner CK, et al. Mol Gen Genet, 1981. PMID 6950197
    5. Multiple molecular forms of xanthine dehydrogenase and related enzymes. Glassman E, et al. Ann N Y Acad Sci, 1968 Jun 14. PMID 5251871

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pyridoxal metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde oxidase 1
    Names
    AOX1-PA
    CG18522-PA
    low-pyridoxal-oxidase
    pyridoxal oxidase
    NP_650475.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15532137..15537292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142218.2 → NP_650475.1  aldehyde oxidase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650475.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF53
      Related
      FBpp0082608
      Conserved Domains (7) summary
      smart01008
      Location:555 → 666
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      PLN02906
      Location:28 → 1259
      PLN02906; xanthine dehydrogenase
      cd00207
      Location:4 → 85
      fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
      pfam01799
      Location:86 → 159
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:711 → 1192
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:399 → 502
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
      cl19922
      Location:211 → 373
      FAD_binding_4; FAD binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF53 Q9VF53

    Gene LinkOut

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