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    gacS sensor/response regulator hybrid protein [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880882, updated on 11-Sep-2024

    Summary

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    Gene symbol
    gacS
    Gene description
    sensor/response regulator hybrid protein
    Locus tag
    PA0928
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1012975..1015752, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene D-lactate dehydrogenase Neighboring gene two-component response regulator Neighboring gene two-component sensor Neighboring gene outer membrane receptor FepA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary relationships among virulence-associated histidine kinases. Brinkman FS, et al. Infect Immun, 2001 Aug. PMID 11447209, Free PMC Article
    2. A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000. O'Malley MR, et al. Mol Plant Pathol, 2020 Jan. PMID 31588661, Free PMC Article
    3. Common virulence factors for bacterial pathogenicity in plants and animals. Rahme LG, et al. Science, 1995 Jun 30. PMID 7604262
    4. Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa. Francis VI, et al. Nat Commun, 2018 Jun 7. PMID 29880803, Free PMC Article
    5. Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa. Mancl JM, et al. Structure, 2019 May 7. PMID 30879888

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS.
      Title: RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS.
    2. A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000.
      Title: A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000.
    3. x-ray crystallography reveals that RetS uses the reversible unfolding of a helix, or helix cracking, to control interactions with GacS
      Title: Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa.
    4. Study interactions between two sensor kinases from Pseudomonas aeruginosa, GacS and RetS, which control the switch between acute and chronic virulence demonstrate three mechanisms by which RetS attenuates GacS signalling: RetS takes phosphoryl groups from GacS-P; RetS has transmitter phosphatase activity against the receiver domain of GacS-P; and RetS inhibits GacS autophosphorylation.
      Title: Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa.
    5. LadS HK thus forms, with the GacS/GacA TCS, a multicomponent signal transduction system with an original phosphorelay cascade, i.e. H1LadS-->D1LadS-->H2GacS-->D2GacA.
      Title: The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa.
    6. The GacS/GacA system transduces the regulatory signals to downstream genes exclusively by directly controlling the expression of only two genes rsmY and rsmZ.
      Title: The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs.
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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables phosphorelay sensor kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of secondary metabolite biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sensor/response regulator hybrid protein
    NP_249619.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1012975..1015752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249619.1 sensor/response regulator hybrid protein [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249619.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK11107
      Location:26 → 900
      PRK11107; hybrid sensory histidine kinase BarA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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