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    ldcA lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878596, updated on 11-Sep-2024

    Summary

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    Gene symbol
    ldcA
    Gene description
    lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA
    Locus tag
    PA1818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1974821..1977076)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene DNA polymerase III subunit epsilon Neighboring gene hypothetical protein Neighboring gene amino acid permease Neighboring gene Na(+)/H(+) antiporter NhaB Neighboring gene enoyl-CoA hydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure, Function, and Evolution of the Pseudomonas aeruginosa Lysine Decarboxylase LdcA. Kandiah E, et al. Structure, 2019 Dec 3. PMID 31653338
    2. A Novel Subfamily of Bacterial AAT-Fold Basic Amino Acid Decarboxylases and Functional Characterization of Its First Representative: Pseudomonas aeruginosa LdcA. Carriel D, et al. Genome Biol Evol, 2018 Nov 1. PMID 30321344, Free PMC Article
    3. L-lysine catabolism is controlled by L-arginine and ArgR in Pseudomonas aeruginosa PAO1. Chou HT, et al. J Bacteriol, 2010 Nov. PMID 20833801, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study identifies LdcA as an important player in P. aeruginosa physiology and virulence and as a potential drug target.
      Title: Structure, Function, and Evolution of the Pseudomonas aeruginosa Lysine Decarboxylase LdcA.
    2. role in producing cadaverine, promoting growth, and reducing persistence during carbenicillin treatment
      Title: A Novel Subfamily of Bacterial AAT-Fold Basic Amino Acid Decarboxylases and Functional Characterization of Its First Representative: Pseudomonas aeruginosa LdcA.
    3. The results of enzyme characterization revealed that this pyridoxal-5-phosphate-dependent decarboxylase takes L-lysine, but not L-arginine, as a substrate.
      Title: L-lysine catabolism is controlled by L-arginine and ArgR in Pseudomonas aeruginosa PAO1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA
    NP_250509.1
    • class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1974821..1977076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250509.1 lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250509.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9I2S7
      Conserved Domains (2) summary
      COG1982
      Location:140 → 751
      LdcC; Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism]
      pfam03709
      Location:22 → 143
      OKR_DC_1_N; Orn/Lys/Arg decarboxylase, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I2S7.1

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