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    liuE 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878857, updated on 11-Sep-2024

    Summary

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    Gene symbol
    liuE
    Gene description
    3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase
    Locus tag
    PA2011
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2199762..2200664, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene homogentisate 1,2-dioxygenase Neighboring gene transcriptional regulator Neighboring gene methylcrotonyl-CoA carboxylase subunit alpha Neighboring gene gamma-carboxygeranoyl-CoA hydratase Neighboring gene methylcrotonyl-CoA carboxylase subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The bifunctional role of LiuE from Pseudomonas aeruginosa, displays additionally HIHG-CoA lyase enzymatic activity. Chávez-Avilés M, et al. Mol Biol Rep, 2010 Apr. PMID 19597963
    2. The Pseudomonas aeruginosa liuE gene encodes the 3-hydroxy-3-methylglutaryl coenzyme A lyase, involved in leucine and acyclic terpene catabolism. Chávez-Avilés M, et al. FEMS Microbiol Lett, 2009 Jul. PMID 19459965
    3. The atu and liu clusters are involved in the catabolic pathways for acyclic monoterpenes and leucine in Pseudomonas aeruginosa. Aguilar JA, et al. Appl Environ Microbiol, 2006 Mar. PMID 16517656, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The LiuE protein displays 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity, indicating a bifunctional role in both the leucine/isovalerate and acyclic terpenes catabolic pathways.
      Title: The bifunctional role of LiuE from Pseudomonas aeruginosa, displays additionally HIHG-CoA lyase enzymatic activity.
    2. These results demonstrate that the liuE gene of P. aeruginosa encodes for the 3-hydroxy-3-methylglutaryl-coenzyme A lyase, an essential enzyme for growth in both leucine and acyclic terpenes.
      Title: The Pseudomonas aeruginosa liuE gene encodes the 3-hydroxy-3-methylglutaryl coenzyme A lyase, involved in leucine and acyclic terpene catabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables hydroxymethylglutaryl-CoA lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-leucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within isoprenoid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within terpene catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase
    NP_250701.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2199762..2200664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250701.1 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250701.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9I2A0
      Conserved Domains (1) summary
      PRK05692
      Location:3 → 289
      PRK05692; hydroxymethylglutaryl-CoA lyase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I2A0.1

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials