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    mexT transcriptional regulator MexT [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880417, updated on 24-Aug-2024

    Summary

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    Gene symbol
    mexT
    Gene description
    transcriptional regulator MexT
    Locus tag
    PA2492
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2807469..2808512)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene oxidoreductase Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux transporter MexF Neighboring gene multidrug efflux outer membrane protein OprN

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome profiling defines a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa. Tian ZX, et al. Nucleic Acids Res, 2009 Dec. PMID 19846594, Free PMC Article
    2. Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF. Luong PM, et al. J Bacteriol, 2014 Jan. PMID 24244000, Free PMC Article
    3. An orphan sensor kinase controls quinolone signal production via MexT in Pseudomonas aeruginosa. Zaoui C, et al. Mol Microbiol, 2012 Feb. PMID 22168309
    4. Iron interferes with quorum sensing-mediated cooperation in Pseudomonas aeruginosa by affecting the expression of ppyR and mexT, in addition to rhlR. Sun F, et al. J Microbiol, 2020 Nov. PMID 32997304
    5. Loss of RNA Chaperone Hfq Unveils a Toxic Pathway in Pseudomonas aeruginosa. Hill IT, et al. J Bacteriol, 2019 Oct 15. PMID 31358608, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iron interferes with quorum sensing-mediated cooperation in Pseudomonas aeruginosa by affecting the expression of ppyR and mexT, in addition to rhlR.
      Title: Iron interferes with quorum sensing-mediated cooperation in Pseudomonas aeruginosa by affecting the expression of ppyR and mexT, in addition to rhlR.
    2. Results identify glutathione to be a factor important for the in vivo activity of MexT. Hfq can influence the growth of P. aeruginosa by limiting the toxic effects of MexT-regulated genes, including hilR.
      Title: Loss of RNA Chaperone Hfq Unveils a Toxic Pathway in Pseudomonas aeruginosa.
    3. Authors show that emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF.
      Title: Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF.
    4. A hybrid sensor kinase controls 2-alkyl-4(1H)-quinolone production via the LysR-type transcriptional regulator MexT.
      Title: An orphan sensor kinase controls quinolone signal production via MexT in Pseudomonas aeruginosa.
    5. Transcription of the mexEF-oprN multidrug efflux pump operon is regulated by MexT.
      Title: Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa.
    6. MexS is a probable oxidoreductase whose expression is dependent on MexT, a LysR-type transcriptional regulator.
      Title: MexT regulates the type III secretion system through MexS and PtrC in Pseudomonas aeruginosa.
    7. MexT activates the expression of a novel regulon by binding to a conserved DNA motif in their promoter regions.
      Title: Transcriptome profiling defines a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa.
    8. The data presented suggest that MexT regulates diverse targets that mediate phenotypic alterations independent of MexEF-OprN.
      Title: MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of secondary metabolite biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional regulator MexT
    NP_251182.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2807469..2808512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251182.1 transcriptional regulator MexT [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251182.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9I0Z0
      Conserved Domains (3) summary
      cd08464
      Location:144 → 340
      PBP2_DntR_like_2; The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold
      COG0583
      Location:80 → 337
      LysR; DNA-binding transcriptional regulator, LysR family [Transcription]
      pfam00126
      Location:80 → 113
      HTH_1; Bacterial regulatory helix-turn-helix protein, lysR family
    Nucleotide Protein
    Heading Accession and Version

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