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    lspA lipoprotein signal peptidase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 877620, updated on 11-Sep-2024

    Summary

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    Gene symbol
    lspA
    Gene description
    lipoprotein signal peptidase
    Locus tag
    PA4559
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5106449..5106958, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene type 4 fimbrial biogenesis protein PilY2 Neighboring gene type 4 fimbrial biogenesis protein PilE Neighboring gene 4-hydroxy-3-methylbut-2-enyl diphosphate reductase Neighboring gene FkbP-type peptidyl-prolyl cis-trans isomerase Neighboring gene isoleucine--tRNA ligase Neighboring gene bifunctional riboflavin kinase/FMN adenylyltransferase Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The lspA gene, encoding the type II signal peptidase of Rickettsia typhi: transcriptional and functional analysis. Rahman MS, et al. J Bacteriol, 2007 Jan. PMID 17098907, Free PMC Article
    2. Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin. Vogeley L, et al. Science, 2016 Feb 19. PMID 26912896
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study reports the crystal structure of LspA from Pseudomonas aeruginosa complexed with the antimicrobial globomycin at 2.8 angstrom resolution.
      Title: Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal peptide processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipoprotein signal peptidase
    NP_253249.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5106449..5106958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253249.1 lipoprotein signal peptidase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253249.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK00376
      Location:6 → 163
      lspA; lipoprotein signal peptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HVM5.1

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