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    lipC lipase LipC [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880125, updated on 24-Aug-2024

    Summary

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    Gene symbol
    lipC
    Gene description
    lipase LipC
    Locus tag
    PA4813
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5402016..5402945, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene nitrate-inducible formate dehydrogenase subunit beta Neighboring gene formate dehydrogenase-O major subunit Neighboring gene 2,4-dienoyl-CoA reductase Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pressure-induced conformational switch of an interfacial protein. Johnson QR, et al. Proteins, 2016 Jun. PMID 26967808
    2. Lipase LipC affects motility, biofilm formation and rhamnolipid production in Pseudomonas aeruginosa. Rosenau F, et al. FEMS Microbiol Lett, 2010 Aug 1. PMID 20546309
    3. LipC, a second lipase of Pseudomonas aeruginosa, is LipB and Xcp dependent and is transcriptionally regulated by pilus biogenesis components. Martínez A, et al. Mol Microbiol, 1999 Oct. PMID 10564475
    4. The lipase LipA (PA2862) but not LipC (PA4813) from Pseudomonas aeruginosa influences regulation of pyoverdine production and expression of the sigma factor PvdS. Funken H, et al. J Bacteriol, 2011 Oct. PMID 21840975, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. By monitoring the width of the access channel, this study found that the protein undergoes a conformational transition and opens the access channel at high hydrostatic pressures (>100 MPa).
      Title: Pressure-induced conformational switch of an interfacial protein.
    2. The LipA (PA2862) but not LipC (PA4813) influences regulation of pyoverdine production and expression of the sigma factor PvdS.
      Title: The lipase LipA (PA2862) but not LipC (PA4813) from Pseudomonas aeruginosa influences regulation of pyoverdine production and expression of the sigma factor PvdS.
    3. LipC is required for motility, biofilm formation and rhamnolipid production.
      Title: Lipase LipC affects motility, biofilm formation and rhamnolipid production in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein secretion by the type II secretion system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport by the Sec complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipase LipC
    NP_253500.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5402016..5402945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253500.1 lipase LipC [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253500.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9HUZ7
      Conserved Domains (1) summary
      COG1075
      Location:18 → 306
      EstA; Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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