U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fimX protein FimX [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878416, updated on 24-Aug-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    fimX
    Gene description
    protein FimX
    Locus tag
    PA4959
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_002516.2 (5565493..5567568)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene phosphatidylserine decarboxylase Neighboring gene cyclic-di-GMP receptor FimW Neighboring gene phosphoserine phosphatase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of an EAL domain in complex with reaction product 5'-pGpG. Robert-Paganin J, et al. PLoS One, 2012. PMID 23285035, Free PMC Article
    2. Interaction of the cyclic-di-GMP binding protein FimX and the Type 4 pilus assembly ATPase promotes pilus assembly. Jain R, et al. PLoS Pathog, 2017 Aug. PMID 28854278, Free PMC Article
    3. Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Navarro MV, et al. Structure, 2009 Aug 12. PMID 19679088, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FimX can promote Type IVa pili assembly when intracellular levels of this cyclic nucleotide are low
      Title: Interaction of the cyclic-di-GMP binding protein FimX and the Type 4 pilus assembly ATPase promotes pilus assembly.
    2. Two crystallographic structures of the EAL domain of FimX (residues 438-686): one of the apo form and the other of a complex with 5'-pGpG, are reported.
      Title: Crystal structure of an EAL domain in complex with reaction product 5'-pGpG.
    3. Data from crystallographic EAL domain dimer suggests modes for the regulation of FimX by c-di-GMP binding.
      Title: Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein FimX
    NP_253646.1
    • class 1: Function experimentally demonstrated in P. aeruginosa

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5565493..5567568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253646.1 protein FimX [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253646.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3M5DLC9
      Conserved Domains (3) summary
      PRK09776
      Location:145 → 683
      PRK09776; putative diguanylate cyclase; Provisional
      cd00156
      Location:11 → 105
      REC; phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs)
      pfam00563
      Location:444 → 678
      EAL; EAL domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases