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    hemD uroporphyrinogen-III synthase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879724, updated on 11-Sep-2024

    Summary

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    Gene symbol
    hemD
    Gene description
    uroporphyrinogen-III synthase
    Locus tag
    PA5259
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5920742..5921497, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene disulfide bond formation protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene porphobilinogen deaminase Neighboring gene alginate biosynthesis regulatory protein AlgR Neighboring gene alginate biosynthesis protein AlgZ/FimS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and properties of uroporphyrinogen III synthase (co-synthase) from an overproducing recombinant strain of Escherichia coli K-12. Alwan AF, et al. Biochem J, 1989 Dec 1. PMID 2557837, Free PMC Article
    2. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    3. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    4. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article
    5. A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. Salunkhe P, et al. J Bacteriol, 2005 Jul. PMID 15995206, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables uroporphyrinogen-III synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uroporphyrinogen-III synthase
    NP_253946.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5920742..5921497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253946.1 uroporphyrinogen-III synthase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253946.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P48246
      Conserved Domains (1) summary
      PRK05752
      Location:1 → 237
      PRK05752; uroporphyrinogen-III synthase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48246.2

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