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    pyd3 pyd3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pyd3provided by FlyBase
    Official Full Name
    pyd3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037513
    Locus tag
    Dmel_CG3027
    See related
    AllianceGenome:FB:FBgn0037513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    betaAS; betaASase; CG3027; Dmel\CG3027
    Summary
    Enables beta-ureidopropionase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process. Located in cytoplasm. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal ectoderm anlage; gnathal primordium; and larval foregut atrium. Orthologous to human UPB1 (beta-ureidopropionase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pyd3 in Genome Data Viewer
    Location:
    84D14-84D14; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7747913..7750079, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3573635..3575801, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44935 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serine protease 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster. Lundgren S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 Oct 1. PMID 17909293, Free PMC Article
    2. The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly. Lundgren S, et al. J Mol Biol, 2008 Apr 11. PMID 18336837
    3. A recruited protease is involved in catabolism of pyrimidines. Andersen B, et al. J Mol Biol, 2008 May 30. PMID 18448119
    4. Eukaryotic beta-alanine synthases are functionally related but have a high degree of structural diversity. Gojković Z, et al. Genetics, 2001 Jul. PMID 11454750, Free PMC Article
    5. Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism. Rawls JM Jr. Genetics, 2006 Mar. PMID 16361227, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-ureidopropionase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-ureidopropionase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleobase catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    pyd3
    Names
    CG3027-PA
    beta-Alanine synthase
    pyd3-PA
    NP_649732.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7747913..7750079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141475.3 → NP_649732.1  pyd3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP10, Q964D7, Q9VI04
      Related
      FBpp0081276
      Conserved Domains (2) summary
      cd07587
      Location:9 → 372
      ML_beta-AS; mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases)
      PLN00202
      Location:9 → 385
      PLN00202; beta-ureidopropionase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI04 Q9VI04

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