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    Srx Sulfiredoxin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srxprovided by FlyBase
    Official Full Name
    Sulfiredoxinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030876
    Locus tag
    Dmel_CG6762
    See related
    AllianceGenome:FB:FBgn0030876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6762; Dmel\CG6762; srx; Srxn
    Summary
    Enables sulfiredoxin activity. Involved in cellular oxidant detoxification. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SRXN1 (sulfiredoxin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Srx in Genome Data Viewer
    Location:
    16E2-16E2; 1-59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17856974..17858610)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17751007..17752643)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Spt7 Neighboring gene antisense RNA:CR43981 Neighboring gene Multicopper oxidase 4 Neighboring gene Actin-related protein 8 Neighboring gene uncharacterized protein Neighboring gene minibrain Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hyperoxidation of Peroxiredoxins and Effects on Physiology of Drosophila. McGinnis A, et al. Antioxidants (Basel), 2021 Apr 15. PMID 33920774, Free PMC Article
    2. JNK signalling regulates antioxidant responses in neurons. Ugbode C, et al. Redox Biol, 2020 Oct. PMID 32949970, Free PMC Article
    3. CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution. Wang Q, et al. Nat Commun, 2021 May 26. PMID 34039988, Free PMC Article
    4. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Kind J, et al. Cell, 2008 May 30. PMID 18510926
    5. Chromosomal instability causes sensitivity to metabolic stress. Shaukat Z, et al. Oncogene, 2015 Jul 30. PMID 25347746

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfiredoxin activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfiredoxin activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sulfiredoxin
    Names
    CG6762-PA
    CG6762-PB
    CG6762-PC
    CG6762-PD
    Srx-PA
    Srx-PB
    Srx-PC
    Srx-PD
    NP_001188665.1
    NP_001188666.1
    NP_001188667.1
    NP_573250.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17856974..17858610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201738.1 → NP_001188667.1  sulfiredoxin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSF0
      Conserved Domains (1) summary
      cl02129
      Location:43 → 146
      ParBc; ParB-like nuclease domain

    2. NM_133022.3 → NP_573250.1  sulfiredoxin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1B2AK28, Q4QPP8, Q9VX10
      Related
      FBpp0074266
      Conserved Domains (1) summary
      cl02129
      Location:53 → 156
      ParBc; ParB-like nuclease domain

    3. NM_001201736.2 → NP_001188665.1  sulfiredoxin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSF7
      Conserved Domains (1) summary
      cl02129
      Location:3 → 106
      ParBc; ParB-like nuclease domain

    4. NM_001201737.2 → NP_001188666.1  sulfiredoxin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSF7
      Conserved Domains (1) summary
      cl02129
      Location:3 → 106
      ParBc; ParB-like nuclease domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSF0 M9MSF0
    M9MSF7 M9MSF7
    Q9VX10.1 Q9VX10

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