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    mmy mummy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33903, updated on 27-Dec-2024

    Summary

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    Official Symbol
    mmyprovided by FlyBase
    Official Full Name
    mummyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259749
    Locus tag
    Dmel_CG9535
    See related
    AllianceGenome:FB:FBgn0259749
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.242; BcDNA:LD24639; cao; CG9535; cys; cyst; cystic; Dmel\CG9535; l(2)k13717b; LD44264; mum; UAP1
    Summary
    Enables UDP-N-acetylglucosamine diphosphorylase activity. Involved in several processes, including amino sugar biosynthetic process; morphogenesis of embryonic epithelium; and nervous system development. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut; hindgut proper primordium; larval tracheal system; and primary tracheal branch. Orthologous to several human genes including UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mmy in Genome Data Viewer
    Location:
    26D7-26D7; 2-20 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6468538..6473904, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6468538..6473904, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ring finger and CHY zinc finger domain containing 1 Neighboring gene HemK methyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene Sec61 alpha subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons. Manavalan MA, et al. Sci Signal, 2017 Jun 20. PMID 28634210, Free PMC Article
    2. Effects of benzoylphenylurea on chitin synthesis and orientation in the cuticle of the Drosophila larva. Gangishetti U, et al. Eur J Cell Biol, 2009 Mar. PMID 18996617
    3. O-GlcNAcylation Dampens Dpp/BMP Signaling to Ensure Proper Drosophila Embryonic Development. Moulton MJ, et al. Dev Cell, 2020 May 4. PMID 32369743
    4. Mummy encodes an UDP-N-acetylglucosamine-dipohosphorylase and is required during Drosophila dorsal closure and nervous system development. Schimmelpfeng K, et al. Mech Dev, 2006 Jun. PMID 16793242
    5. Tubulogenesis: an inside job. Swanson LE, et al. Curr Biol, 2006 Jan 24. PMID 16431358, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mmy is required for Slit secretion and for maintaining Robo abundance and distribution in the developing nervous system in Drosophila.
      Title: The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons.
    2. mmy is essential for multiple developmental events in Drosophila.
      Title: Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine diphosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine diphosphorylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic epithelial tube formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mummy
    Names
    CG9535-PA
    CG9535-PB
    CG9535-PD
    UDP-GlcNAc pyrophosphorylase
    UDP-N-acetylglucosamine diphosphorylase
    UDP-N-acetylglucosamine pyrophosphorylase
    cabrio
    cystic
    mmy-PA
    mmy-PB
    mmy-PD
    NP_001285673.1
    NP_609032.1
    NP_723183.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6468538..6473904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298744.1 → NP_001285673.1  mummy, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGT8, Q8IPJ6
      Conserved Domains (2) summary
      cd04193
      Location:88 → 410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
      cl21455
      Location:1 → 86
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_164690.2 → NP_723183.1  mummy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGT8, Q8IPJ6
      Related
      FBpp0078899
      Conserved Domains (2) summary
      cd04193
      Location:88 → 410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
      cl21455
      Location:1 → 86
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_135188.3 → NP_609032.1  mummy, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609032.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGT8, Q9Y0Z0
      Related
      FBpp0078898
      Conserved Domains (2) summary
      cd04193
      Location:125 → 447
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
      cl21455
      Location:34 → 123
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGT8 Q8IGT8
    Q8IPJ6 Q8IPJ6
    Q9Y0Z0 Q9Y0Z0

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