Ddc Dopa decarboxylase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ddcprovided by FlyBase
Official Full Name: Dopa decarboxylaseprovided by FlyBase
Primary source: FLYBASE:FBgn0000422
Locus tag: Dmel_CG10697
See related: AllianceGenome:FB:FBgn0000422
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AADC; CG10697; ddc; DDC; DdcDm; Dmel\CG10697; fDDC; l(2)37Bl; l(2)37Ch; l(2)k02104
Summary: Enables 5-hydroxy-L-tryptophan decarboxylase activity and L-dopa decarboxylase activity. Involved in several processes, including adult chitin-containing cuticle pigmentation; aromatic amino acid metabolic process; and memory. Predicted to be active in cytoplasm. Is expressed in several structures, including aminergic neurons; epithelium; ganglia; gut section; and mushroom body medial lobe. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 37C1-37C1; 2-54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19116483..19120306, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19116483..19120306, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lowered expression of Atg6 or Pi3K59F in Ddc-Gal4-expressing neurons results in decreased longevity and associated age-dependent loss of locomotor ability. Inhibition of Atg6 or Pi3K59F together with overexpression of the sole pro-survival Bcl-2 Drosophila homolog Buffy in Ddc-Gal4-expressing neurons resulted in further decrease in the survival
Title: Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogaster.
The involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria.
Title: A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response.
The Ddc locus exhibits a complicated pattern of variation apparently due to several evolutionary forces.
Title: Nucleotide variation at the dopa decarboxylase (Ddc) gene in natural populations of Drosophila melanogaster.
evidence for a wound response pathway that senses aseptic breaks in the barrier epidermis of Drosophila embryos; a minimal 472-bp Ddc wound response enhancer requires a Grh protein binding site and the function of the grh gene
Title: An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head.
epidermal Ddc induction at pupariation is under the control of an extended genomic region that contains both positive and negative regulatory elements
Title: Induction of the early-late Ddc gene during Drosophila metamorphosis by the ecdysone receptor.
Broad-Complex protein is required for Ddc activation at eclosion in Drosophila
Title: Control of Dopa decarboxylase gene expression by the Broad-Complex during metamorphosis in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 5-hydroxy-L-tryptophan decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-dopa decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatic-L-amino-acid decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatic-L-amino-acid decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatic-L-amino-acid decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult chitin-containing cuticle pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in anesthesia-resistant memory	IDA Inferred from Direct Assay more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine biosynthetic process from tyrosine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of adult chitin-containing cuticle pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of adult chitin-containing cuticle pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	IEP Inferred from Expression Pattern more info	PubMed
involved_in serotonin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin biosynthetic process from tryptophan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dopa decarboxylase

Names: 3,4-Dihydroxyphenylalanine decarboxylase; CG10697-PB; CG10697-PC; CG10697-PD; Ddc-PB; Ddc-PC; Ddc-PD; L-3,4-dihydroxyphenylalanine decarboxylase; L-dopa decarboxylase; aromatic L-amino acid decarboxylase; aromatic amino acid decarboxylase; dopa-decarboxylase; dopadecarboxylase; dopamine decarboxylase; transcription unit No. 3

NP_523600.5

EC 4.1.-.-

EC 4.1.1.-

EC 4.1.1.28

NP_724163.1

EC 4.1.-.-

EC 4.1.1.-

EC 4.1.1.28

NP_724164.1

EC 4.1.-.-

EC 4.1.1.-

EC 4.1.1.28

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

19116483..19120306 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165280.2 → NP_724164.1 dopa decarboxylase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724164.1

Status: REVIEWED

UniProtKB/TrEMBL

F0JAJ7

Related

FBpp0080709

Conserved Domains (1) summary

pfam00282
Location:35 → 411

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
NM_165279.2 → NP_724163.1 dopa decarboxylase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724163.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18379, P05031, P05032, Q24295, Q7YSJ0, Q7YSK5, Q7YSV6, Q7Z0E1, Q7Z0E2, Q7Z0E3, Q7Z0E4, Q7Z0E5, Q7Z0E6, Q7Z0E7, Q7Z0E8, Q7Z0E9, Q95SL9, Q9VIZ5, Q9VIZ6

UniProtKB/TrEMBL

F0JAJ6

Related

FBpp0080710

Conserved Domains (1) summary

pfam00282
Location:70 → 446

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
NM_078876.5 → NP_523600.5 dopa decarboxylase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523600.5

Status: REVIEWED

UniProtKB/TrEMBL

F0JAJ7

Conserved Domains (1) summary

pfam00282
Location:35 → 411

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain