Hopx HOP homeobox [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hopxprovided by RGD
Full Name: HOP homeoboxprovided by RGD
Primary source: RGD:621841
See related: EnsemblRapid:ENSRNOG00000024689 AllianceGenome:RGD:621841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hod; Obl; GIIg15b
Summary: Predicted to enable histone deacetylase regulator activity. Predicted to be involved in chaperone-mediated protein complex assembly; positive regulation of gap junction assembly; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including lung alveolus development; positive regulation of skeletal muscle tissue regeneration; and trophectodermal cell differentiation. Predicted to be active in nucleus. Orthologous to human HOPX (HOP homeobox). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 2052.4), Heart (RPKM 241.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (31410235..31437189)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (31055912..31082909)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (33354803..33362547)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy.
Title: HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase regulator activity	ISO Inferred from Sequence Orthology more info
NOT enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gap junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within trophectodermal cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeodomain-only protein

Names: global ischemia induced protein GIIG15B; global ischemia-induced gene 15B protein; global ischemia-induced protein 15B; homeobox only domain; odd homeobox 1; odd homeobox protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133621.3 → NP_598305.2 homeodomain-only protein

See identical proteins and their annotated locations for NP_598305.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q78ZR5, Q8R4G4

UniProtKB/TrEMBL

A6JCV9

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

31410235..31437189

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091595.2 → XP_038947523.1 homeodomain-only protein isoform X1

UniProtKB/Swiss-Prot

Q78ZR5, Q8R4G4

UniProtKB/TrEMBL

A6JCV9

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_039091596.1 → XP_038947524.1 homeodomain-only protein isoform X1

UniProtKB/Swiss-Prot

Q78ZR5, Q8R4G4

UniProtKB/TrEMBL

A6JCV9

Related

ENSRNOP00000044357.4, ENSRNOT00000049774.6

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_039091597.2 → XP_038947525.1 homeodomain-only protein isoform X1

UniProtKB/Swiss-Prot

Q78ZR5, Q8R4G4

UniProtKB/TrEMBL

A6JCV9

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_039091598.2 → XP_038947526.1 homeodomain-only protein isoform X1

UniProtKB/Swiss-Prot

Q78ZR5, Q8R4G4

UniProtKB/TrEMBL

A6JCV9

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.