Chrna10 cholinergic receptor nicotinic alpha 10 subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chrna10provided by RGD
Official Full Name: cholinergic receptor nicotinic alpha 10 subunitprovided by RGD
Primary source: RGD:620142
See related: EnsemblRapid:ENSRNOG00000020293 AllianceGenome:RGD:620142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in negative regulation of ERK1 and ERK2 cascade. Located in axon and perikaryon. Is active in cholinergic synapse and postsynaptic specialization membrane. Orthologous to human CHRNA10 (cholinergic receptor nicotinic alpha 10 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 7.0), Lung (RPKM 1.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (165898932..165905348, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (156487279..156494277, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (167206722..167212199, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Key role of the TM2-TM3 loop in calcium potentiation of the alpha9alpha10 nicotinic acetylcholine receptor.
Title: Key role of the TM2-TM3 loop in calcium potentiation of the α9α10 nicotinic acetylcholine receptor.
the contribution of subunit interface domains to alpha9alpha10 receptors by a combination of electrophysiological and radioligand binding studies, is reported.
Title: Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function.
A two order of magnitude species difference in potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10 nAChR.
Title: Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.
mRNA expression of the nicotinic acetylcholine receptor alpha9 subunit precedes expression of the alpha10 subunit in both cochlear and vestibular hair cells.
Title: Spatial and temporal expression patterns of nicotinic acetylcholine α9 and α10 subunits in the embryonic and early postnatal inner ear.
The properties of rat and chicken recombinant and native alpha9alpha10 receptors, were compared.
Title: Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor.
Co-expression of the alpha10 subunit converts the normally weak acetylcholine-mediated activity of alpha9 to a more robustly active channel with identical physiological characteristics of the native mammalian outer hair cell cholinergic receptor.
Title: alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells.
Dorsal root ganglion neurons coexpress alpha 10 nicotinic acetylcholine receptor subunit with the alpha 9 subunit, thereby providing the first example of neuronal expression of this receptor subunit pair.
Title: Coexpression of alpha 9 and alpha 10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons.
Results suggest a molecular mechanism for the treatment of neuropathic pain and also demonstrate the involvement of alpha9alpha10 nicotinic acetylcholine receptors in the pathophysiology of peripheral nerve injury.
Title: Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors.
Nicotinic acetylcholine receptor alpha 10 subunit is localized in virtually all nociceptive neurons that are identified by immunoreactivity for the vanilloid receptor TRPV-1.
Title: Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat.
Allografts were characterized by accumulations of alveolar macrophages strongly expressing the alpha9 and the alpha10 receptor subunit.
Title: Immunohistochemical detection of nicotinic acetylcholine receptor subunits alpha9 and alpha10 in rat lung isografts and allografts.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, cholinergic	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cholinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit alpha-10

Names: NACHR alpha-10; cholinergic receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 10; neuronal nicotinic acetylcholine receptor subunit; nicotinic acetylcholine receptor subunit alpha-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022639.1 → NP_072161.1 neuronal acetylcholine receptor subunit alpha-10 precursor

See identical proteins and their annotated locations for NP_072161.1

Status: PROVISIONAL

Source sequence(s)

AF196344

UniProtKB/Swiss-Prot

Q9JLB5

UniProtKB/TrEMBL

A6I720

Related

ENSRNOP00000027506.2, ENSRNOT00000027507.5

Conserved Domains (2) summary

pfam02931
Location:32 → 235

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:243 → 437

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

165898932..165905348 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272783.1 → XP_063128853.1 neuronal acetylcholine receptor subunit alpha-10 isoform X2

UniProtKB/Swiss-Prot

Q9JLB5

UniProtKB/TrEMBL

A6I720
XM_006229891.5 → XP_006229953.1 neuronal acetylcholine receptor subunit alpha-10 isoform X1

Conserved Domains (3) summary

TIGR00860
Location:60 → 476

LIC; Cation transporter family protein

pfam02931
Location:77 → 280

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:288 → 482

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region