Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj4provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 4provided by RGD
Primary source: RGD:621436
See related: EnsemblRapid:ENSRNOG00000013869 AllianceGenome:RGD:621436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hirk2
Summary: Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Involved in cellular response to mechanical stimulus. Located in dendrite and neuronal cell body. Orthologous to human KCNJ4 (potassium inwardly rectifying channel subfamily J member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 73.5) and Lung (RPKM 12.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112927494..112954547, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111047097..111074151, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120717378..120744602, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down-regulation of the Kir2.3 channel expression contributes to the pathogenesis of temporal lobe epilepsy.
Title: Tenidap, an agonist of the inwardly rectifying K+ channel Kir2.3, delays the onset of cortical epileptiform activity in a model of chronic temporal lobe epilepsy.
Immunohistochemical analysis reveals the expression of Kir2.1, Kir2.2, and Kir2.3/Kcnj4 within spontaneously bursting neurons that regulate the level of pacemaker activity within the developing superficial dorsal horn.
Title: Inward-rectifying potassium (Kir) channels regulate pacemaker activity in spinal nociceptive circuits during early life.
Immunochemical staining verified that both pericytes and endothelial cells of descending vasa recta express K(IR)2.1, K(IR)2.2, and K(IR)2.3 subunits.
Title: Descending vasa recta endothelia express inward rectifier potassium channels.
These studies provide an entry point for understanding the novel roles of Kir2.3 in cell models of PD, and they offer clues for the common mechanisms underlying different neurodegenerative conditions.
Title: Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inward rectifier potassium channel 4

Names: BIR11; IRK-3; IRK3; brain inwardly rectifying K(+) channel 2; inward rectifier K(+) channel Kir2.3; potassium channel, inwardly rectifying subfamily J member 4; potassium voltage-gated channel subfamily J member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.