Thrsp thyroid hormone responsive [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thrspprovided by RGD
Official Full Name: thyroid hormone responsiveprovided by RGD
Primary source: RGD:3859
See related: EnsemblRapid:ENSRNOG00000012404 AllianceGenome:RGD:3859
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S14; Lpgp; SPOT14
Summary: Predicted to enable molecular function inhibitor activity and protein homodimerization activity. Involved in regulation of lipid biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human THRSP (thyroid hormone responsive). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 3623.0), Thymus (RPKM 3588.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (161134640..161138964, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (151723415..151727740, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (162381251..162385575, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data support the hypothesis that both S14 and S14R are directly involved in supporting hepatic lipogenesis and that the two proteins play overlapping roles in this process.
Title: Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis.
Anabolic mechanical stimulation (45 Hz, 10 min/day at 0.25 g) did not show a statistically significant effect on S14 expression.
Title: The lipogenic gene spot 14 is activated in bone by disuse yet remains unaffected by a mechanical signal anabolic to the skeleton.
It is concluded that THRP is an important factor in thyroid hormone-induced neuronal cell death.
Title: Thyroid hormone responsive protein (THRP) mediates thyroid hormone-induced cytotoxicity in primary neuronal cultures.
significantly greater thyroid hormone response for the human promoter, compared with the rat
Title: Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification.
Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene 1 and thyroid hormone responsive protein genes)
Title: Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene 1 and thyroid hormone responsive protein genes).

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General gene information

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Markers

RH135409 (e-PCR)
- UniSTS:218686

D1Arb38 (e-PCR)
- UniSTS:517798

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyroid hormone-inducible hepatic protein

Names: Lipogenic protein S14; spot 14 protein; thyroid hormone responsive SPOT14 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.