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    Celf5 CUGBP, Elav-like family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314647, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Celf5provided by RGD
    Official Full Name
    CUGBP, Elav-like family member 5provided by RGD
    Primary source
    RGD:1565016
    See related
    EnsemblRapid:ENSRNOG00000004695 AllianceGenome:RGD:1565016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brunol5; RGD1565016
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CELF5 (CUGBP Elav-like family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 55.2) and Testes (RPKM 3.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Celf5 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8876551..8901078)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8225787..8250322)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11095449..11119941)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene nicalin Neighboring gene nuclear factor I/C Neighboring gene uncharacterized LOC120093769 Neighboring gene small integral membrane protein 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Ladd AN, et al. Mol Cell Biol, 2001 Feb. PMID 11158314, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CUGBP Elav-like family member 5
    Names
    CUG-BP- and ETR-3-like factor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135603.3 → NP_001129075.1  CUGBP Elav-like family member 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000103307.1, ENSRNOT00000161972.1
      Conserved Domains (3) summary
      TIGR01628
      Location:9 → 356
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:95 → 175
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8876551..8901078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240942.5 → XP_006241004.2  CUGBP Elav-like family member 5 isoform X2

      Conserved Domains (4) summary
      TIGR01628
      Location:9 → 357
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12639
      Location:356 → 434
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:94 → 174
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    2. XM_039079023.2 → XP_038934951.1  CUGBP Elav-like family member 5 isoform X1

      UniProtKB/TrEMBL
      D4A8V0
      Related
      ENSRNOP00000057932.3, ENSRNOT00000061219.4
      Conserved Domains (4) summary
      TIGR01628
      Location:9 → 358
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12639
      Location:357 → 435
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:95 → 175
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    3. XM_017594819.3 → XP_017450308.1  CUGBP Elav-like family member 5 isoform X3

      Conserved Domains (3) summary
      TIGR01628
      Location:9 → 355
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:94 → 174
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    4. XM_008765105.4 → XP_008763327.1  CUGBP Elav-like family member 5 isoform X8

      Conserved Domains (3) summary
      cd12639
      Location:281 → 359
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:5 → 361
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:19 → 99
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    5. XM_063263433.1 → XP_063119503.1  CUGBP Elav-like family member 5 isoform X13

    6. XM_063263431.1 → XP_063119501.1  CUGBP Elav-like family member 5 isoform X12

      UniProtKB/TrEMBL
      A6K877

    7. XM_063263432.1 → XP_063119502.1  CUGBP Elav-like family member 5 isoform X12

      UniProtKB/TrEMBL
      A6K877

    8. XM_039079024.2 → XP_038934952.1  CUGBP Elav-like family member 5 isoform X4

      Conserved Domains (3) summary
      cd12639
      Location:315 → 393
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:39 → 395
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:53 → 133
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    9. XM_039079025.2 → XP_038934953.1  CUGBP Elav-like family member 5 isoform X5

      Conserved Domains (3) summary
      cd12639
      Location:314 → 392
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:42 → 394
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:52 → 132
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    10. XM_039079026.2 → XP_038934954.1  CUGBP Elav-like family member 5 isoform X9

      Conserved Domains (2) summary
      TIGR01628
      Location:31 → 313
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:52 → 132
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    11. XM_063263430.1 → XP_063119500.1  CUGBP Elav-like family member 5 isoform X10

    12. XM_008765104.4 → XP_008763326.1  CUGBP Elav-like family member 5 isoform X6

      Conserved Domains (3) summary
      cd12635
      Location:25 → 105
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:287 → 365
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:11 → 367
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    13. XM_039079027.2 → XP_038934955.1  CUGBP Elav-like family member 5 isoform X7

      Conserved Domains (3) summary
      cd12639
      Location:286 → 364
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:14 → 366
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:24 → 104
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    14. XM_039079028.2 → XP_038934956.1  CUGBP Elav-like family member 5 isoform X11

      Conserved Domains (2) summary
      TIGR01628
      Location:27 → 285
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:24 → 104
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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