Sppl2b signal peptide peptidase-like 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sppl2bprovided by RGD
Official Full Name: signal peptide peptidase-like 2Bprovided by RGD
Primary source: RGD:1308556
See related: EnsemblRapid:ENSRNOG00000057881 AllianceGenome:RGD:1308556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308556
Summary: Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in several cellular components, including cytoskeleton; endosome membrane; and nucleoplasm. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Orthologous to human SPPL2B (signal peptide peptidase like 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 60.0), Kidney (RPKM 58.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9494593..9507317, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8843918..8856642, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11712187..11724915, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic endopeptidase activity, intramembrane cleaving	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic endopeptidase activity, intramembrane cleaving	IEA Inferred from Electronic Annotation more info
NOT enables aspartic endopeptidase activity, intramembrane cleaving	ISO Inferred from Sequence Orthology more info
enables aspartic endopeptidase activity, intramembrane cleaving	ISO Inferred from Sequence Orthology more info
NOT enables aspartic endopeptidase activity, intramembrane cleaving	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane protein intracellular domain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in membrane protein intracellular domain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein intracellular domain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane protein proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in Golgi-associated vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi-associated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic side of endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lumenal side of endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lumenal side of endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lumenal side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in lumenal side of endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: signal peptide peptidase-like 2B

Names: SPP-like 2B; presenilin-like protein 1; protein SPP-like 2B; protein SPPL2b

NP_001014222.1

EC 3.4.23.-

NP_001388002.1

EC 3.4.23.-

NP_001388003.1

EC 3.4.23.-

XP_006241010.1

EC 3.4.23.-

XP_008763332.2

EC 3.4.23.-

XP_008763333.1

EC 3.4.23.-

XP_008763334.1

EC 3.4.23.-

XP_038935313.1

EC 3.4.23.-

XP_038935314.1

EC 3.4.23.-

XP_038935317.1

EC 3.4.23.-

XP_063119791.1

EC 3.4.23.-

XP_063119793.1

EC 3.4.23.-

XP_063119794.1

EC 3.4.23.-

XP_063119795.1

EC 3.4.23.-

XP_063119796.1

EC 3.4.23.-

XP_063119797.1

EC 3.4.23.-

XP_063119798.1

EC 3.4.23.-

XP_063119800.1

EC 3.4.23.-

XP_063119801.1

EC 3.4.23.-

XP_063119802.1

EC 3.4.23.-

XP_063119803.1

EC 3.4.23.-

XP_063119804.1

EC 3.4.23.-

XP_063119805.1

EC 3.4.23.-

XP_063119806.1

EC 3.4.23.-

XP_063119807.1

EC 3.4.23.-

XP_063119809.1

EC 3.4.23.-

XP_063119810.1

EC 3.4.23.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014200.2 → NP_001014222.1 signal peptide peptidase-like 2B isoform 2 precursor

See identical proteins and their annotated locations for NP_001014222.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q5PQL3

UniProtKB/TrEMBL

A0A8I5ZVS2

Related

ENSRNOP00000081849.1, ENSRNOT00000109298.2

Conserved Domains (2) summary

cd02129
Location:38 → 157

PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...

pfam04258
Location:206 → 498

Peptidase_A22B; Signal peptide peptidase
NM_001401073.1 → NP_001388002.1 signal peptide peptidase-like 2B isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5ZVS2, A6K8E3

Related

ENSRNOP00000074120.3, ENSRNOT00000084144.3
NM_001401074.1 → NP_001388003.1 signal peptide peptidase-like 2B isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5ZVS2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9494593..9507317 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263736.1 → XP_063119806.1 signal peptide peptidase-like 2B isoform X19

UniProtKB/TrEMBL

A0A8I5ZVS2
XM_063263734.1 → XP_063119804.1 signal peptide peptidase-like 2B isoform X17

UniProtKB/TrEMBL

A0A8I5ZVS2
XM_063263735.1 → XP_063119805.1 signal peptide peptidase-like 2B isoform X18

UniProtKB/TrEMBL

A0A8I5ZVS2
XM_006240948.3 → XP_006241010.1 signal peptide peptidase-like 2B isoform X11

UniProtKB/TrEMBL

A0A8I5ZVS2, A0A8L2R960

Conserved Domains (2) summary

cd02129
Location:38 → 157

PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...

pfam04258
Location:206 → 498

Peptidase_A22B; Signal peptide peptidase
XM_063263732.1 → XP_063119802.1 signal peptide peptidase-like 2B isoform X13

UniProtKB/TrEMBL

A0A8I6GG67
XM_063263726.1 → XP_063119796.1 signal peptide peptidase-like 2B isoform X5

UniProtKB/TrEMBL

A0A8I5ZVS2
XM_008765112.3 → XP_008763334.1 signal peptide peptidase-like 2B isoform X8

UniProtKB/TrEMBL

A0A8I5ZVS2

Conserved Domains (2) summary

cd02129
Location:38 → 157

PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...

pfam04258
Location:206 → 551

Peptidase_A22B; Signal peptide peptidase
XM_063263723.1 → XP_063119793.1 signal peptide peptidase-like 2B isoform X2
XM_039079386.1 → XP_038935314.1 signal peptide peptidase-like 2B isoform X15

UniProtKB/TrEMBL

A0A8I5ZVS2

Conserved Domains (2) summary

cd02129
Location:38 → 157

PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...

pfam04258
Location:207 → 474

Peptidase_A22B; Signal peptide peptidase
XM_063263727.1 → XP_063119797.1 signal peptide peptidase-like 2B isoform X6

UniProtKB/TrEMBL

A0A8I5ZVS2
XM_063263733.1 → XP_063119803.1 signal peptide peptidase-like 2B isoform X16

UniProtKB/TrEMBL

A0A8I5ZVS2
XM_063263725.1 → XP_063119795.1 signal peptide peptidase-like 2B isoform X4

UniProtKB/TrEMBL

A0A8I5ZVS2
XM_063263724.1 → XP_063119794.1 signal peptide peptidase-like 2B isoform X3
XM_008765110.3 → XP_008763332.2 signal peptide peptidase-like 2B isoform X9

UniProtKB/TrEMBL

A0A8I5ZVS2
XM_008765111.3 → XP_008763333.1 signal peptide peptidase-like 2B isoform X7

UniProtKB/TrEMBL

A0A8I5ZVS2

Conserved Domains (2) summary

cd02129
Location:38 → 157

PA_hSPPL_like; PA_hSPPL_like: Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the ...

pfam04258
Location:207 → 552

Peptidase_A22B; Signal peptide peptidase
XM_063263728.1 → XP_063119798.1 signal peptide peptidase-like 2B isoform X10

UniProtKB/TrEMBL

A0A8I6GG67
XM_063263721.1 → XP_063119791.1 signal peptide peptidase-like 2B isoform X1
XM_063263731.1 → XP_063119801.1 signal peptide peptidase-like 2B isoform X12
XM_063263730.1 → XP_063119800.1 signal peptide peptidase-like 2B isoform X12
XM_063263740.1 → XP_063119810.1 signal peptide peptidase-like 2B isoform X22
XM_063263737.1 → XP_063119807.1 signal peptide peptidase-like 2B isoform X20
XM_063263739.1 → XP_063119809.1 signal peptide peptidase-like 2B isoform X21
XM_039079385.2 → XP_038935313.1 signal peptide peptidase-like 2B isoform X14

UniProtKB/TrEMBL

A0A8I6GG67

Conserved Domains (2) summary

cd02129
Location:38 → 157

PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...

pfam04258
Location:207 → 552

Peptidase_A22B; Signal peptide peptidase
XM_039079389.2 → XP_038935317.1 signal peptide peptidase-like 2B isoform X23

Conserved Domains (2) summary

cd02129
Location:38 → 157

PA_hSPPL_like; Protease-associated domain containing human signal peptide peptidase-like (hSPPL)-like. This group contains various PA domain-containing proteins similar to hSPPL2a and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is sorted to the late endosomes, ...

cl01342
Location:207 → 311

Peptidase_A22B; Signal peptide peptidase