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    Eif2s2 eukaryotic translation initiation factor 2 subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif2s2provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 2 subunit betaprovided by RGD
    Primary source
    RGD:735192
    See related
    EnsemblRapid:ENSRNOG00000017447 AllianceGenome:RGD:735192
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to act upstream of or within in utero embryonic development; male germ cell proliferation; and male gonad development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Predicted to be active in synapse. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 723.9), Testes (RPKM 497.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif2s2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163834846..163855733, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143374652..143395460, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150391455..150412179, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L38 like 6 Neighboring gene RALY heterogeneous nuclear ribonucleoprotein Neighboring gene Sec61 translocon subunit gamma, pseudogene 7 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene agouti signaling protein Neighboring gene transfer RNA alanine (anticodon AGC) 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Shape and location of eukaryotic initiation factor eIF-2 on the 40S ribosomal subunit of rat liver. Immunoelectron-microscopic and hydrodynamic investigations. Bommer UA, et al. Eur J Biochem, 1988 Mar 15. PMID 2450747
    2. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Heaney JD, et al. Hum Mol Genet, 2009 Apr 15. PMID 19168544, Free PMC Article
    3. Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. Ben-Asouli Y, et al. Nucleic Acids Res, 2000 Feb 15. PMID 10648795, Free PMC Article
    4. eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. Borck G, et al. Mol Cell, 2012 Nov 30. PMID 23063529, Free PMC Article
    5. Modulation of protein translation by Nck-1. Kebache S, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11959995, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male germ cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 2
    Names
    eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199380.1 → NP_955412.1  eukaryotic translation initiation factor 2 subunit 2

      See identical proteins and their annotated locations for NP_955412.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062402
      UniProtKB/TrEMBL
      A0A8I6A6W5, A6KI11, F7FE42, Q6P685
      Related
      ENSRNOP00000081256.2, ENSRNOT00000110685.2
      Conserved Domains (1) summary
      smart00653
      Location:199 → 308
      eIF2B_5; domain present in translation initiation factor eIF2B and eIF5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      163834846..163855733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283372.1 → XP_063139442.1  eukaryotic translation initiation factor 2 subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6W5

    2. XM_063283373.1 → XP_063139443.1  eukaryotic translation initiation factor 2 subunit 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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