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    Sdr Secreted decoy of InR [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sdrprovided by FlyBase
    Official Full Name
    Secreted decoy of InRprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038279
    Locus tag
    Dmel_CG3837
    See related
    AllianceGenome:FB:FBgn0038279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3837; Dmel\CG3837; SDR
    Summary
    Enables insulin-like growth factor binding activity. Involved in several processes, including imaginal disc fusion, thorax closure; negative regulation of insulin receptor signaling pathway; and response to starvation. Located in extracellular space. Is expressed in several structures, including embryonic/larval hemolymph; embryonic/larval midgut; imaginal disc; larval central nervous system; and larval visceral muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sdr in Genome Data Viewer
    Location:
    88D7-88D7; 3-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14918628..14923083)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10744350..10748805)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase PPA1 subunit 1 Neighboring gene long non-coding RNA:CR46199 Neighboring gene long non-coding RNA:CR45598 Neighboring gene long non-coding RNA:CR45599

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Secreted decoy of insulin receptor is required for blood-brain and blood-retina barrier integrity in Drosophila. Kim J, et al. BMB Rep, 2023 Apr. PMID 36593109, Free PMC Article
    2. A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila. Yamada T, et al. Nat Metab, 2020 Oct. PMID 33046910
    3. Glycolytically impaired Drosophila glial cells fuel neural metabolism via β-oxidation. McMullen E, et al. Nat Commun, 2023 May 24. PMID 37225684, Free PMC Article
    4. Body size regulation and insulin-like growth factor signaling. Hyun S. Cell Mol Life Sci, 2013 Jul. PMID 23508807, Free PMC Article
    5. A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila. Okamoto N, et al. Genes Dev, 2013 Jan 1. PMID 23307869, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables ATP binding IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables insulin-like growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables transmembrane receptor protein tyrosine kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in membrane IKR
    Inferred from Key Residues
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secreted decoy of InR
    Names
    CG3837-PA
    CG3837-PB
    Sdr-PA
    Sdr-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14918628..14923083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300402.1 → NP_001287331.1  secreted decoy of InR, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNJ6, Q9VFE2
      Conserved Domains (3) summary
      smart00060
      Location:491 → 578
      FN3; Fibronectin type 3 domain
      pfam00757
      Location:209 → 332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:347 → 461
      Recep_L_domain; Receptor L domain

    2. NM_142151.2 → NP_650408.1  secreted decoy of InR, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNJ6, Q9VFE2
      Related
      FBpp0082463
      Conserved Domains (3) summary
      smart00060
      Location:491 → 578
      FN3; Fibronectin type 3 domain
      pfam00757
      Location:209 → 332
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:347 → 461
      Recep_L_domain; Receptor L domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T001 Q8T001
    Q9VFE2 Q9VFE2

    Gene LinkOut

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