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    Rab5a RAB5A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64633, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab5aprovided by RGD
    Official Full Name
    RAB5A, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:620936
    See related
    EnsemblRapid:ENSRNOG00000057056 AllianceGenome:RGD:620936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GDP-dissociation inhibitor binding activity. Involved in several processes, including positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; and vesicle-mediated transport in synapse. Located in several cellular components, including cytoplasmic vesicle; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in cytoplasmic vesicle; glutamatergic synapse; and postsynaptic endocytic zone membrane. Orthologous to human RAB5A (RAB5A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Rab5a in Genome Data Viewer
    Location:
    9q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (6720057..6749456)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6483906..6512877)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (5910..6065, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene EF hand domain family, member B Neighboring gene transfer RNA serine (anticodon AGA) 49 Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene lysine acetyltransferase 2B Neighboring gene small nucleolar RNA SNORA48 Neighboring gene shugoshin 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity  
    enables GDP binding  
    enables GDP-dissociation inhibitor binding PubMed 
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables guanyl nucleotide binding  
    enables membrane scission GTPase motor activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance by transcytosis  
    involved_in canonical Wnt signaling pathway  
    involved_in early endosome to late endosome transport  
    involved_in endocytosis  
    involved_in endocytosis PubMed 
    acts_upstream_of_or_within endocytosis  
    involved_in endocytosis  
    involved_in endosome organization PubMed 
    involved_in intracellular protein transport  
    involved_in phagocytosis  
    involved_in positive regulation of exocytosis  
    involved_in positive regulation of smooth muscle cell migration PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in protein transport  
    involved_in receptor internalization  
    involved_in regulation of endosome size  
    involved_in regulation of filopodium assembly  
    involved_in regulation of long-term neuronal synaptic plasticity  
    involved_in regulation of long-term neuronal synaptic plasticity PubMed 
    involved_in regulation of synaptic vesicle exocytosis  
    involved_in regulation of synaptic vesicle exocytosis  
    involved_in synaptic vesicle endocytosis PubMed 
    involved_in synaptic vesicle endocytosis PubMed 
    involved_in synaptic vesicle recycling  
    involved_in vesicle-mediated transport PubMed 
    Items 1 - 25 of 27
    Items 1 - 20 of 58
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    is_active_in axon  
    located_in axon PubMed 
    located_in axon terminus PubMed 
    located_in cytoplasm  
    located_in cytoplasmic side of early endosome membrane  
    located_in cytosol  
    is_active_in dendrite  
    located_in dendrite PubMed 
    located_in early endosome PubMed 
    located_in early endosome  
    located_in early endosome  
    located_in early endosome membrane  
    located_in early phagosome  
    located_in early phagosome  
    is_active_in endocytic vesicle  
    located_in endocytic vesicle  
    is_active_in endomembrane system  
    located_in endosome PubMed 
    located_in endosome  
    located_in endosome membrane  
    located_in exocytic vesicle  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in lipid droplet  
    located_in melanosome  
    located_in membrane raft  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic early endosome  
    is_active_in postsynaptic endocytic zone membrane PubMed 
    is_active_in postsynaptic endocytic zone membrane PubMed 
    is_active_in presynaptic endosome PubMed 
    is_active_in presynaptic endosome PubMed 
    part_of protein-containing complex PubMed 
    located_in recycling endosome PubMed 
    located_in ruffle  
    located_in somatodendritic compartment PubMed 
    located_in somatodendritic compartment  
    located_in sorting endosome  
    located_in synaptic vesicle PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    located_in terminal bouton PubMed 
    located_in terminal bouton  
    located_in terminal bouton  
    located_in zymogen granule membrane PubMed 
    Items 1 - 20 of 58

    General protein information

    Preferred Names
    ras-related protein Rab-5A
    Names
    small GTP-binding protein rab5
    NP_073183.1
    XP_038940106.1
    XP_038940109.1
    XP_063123761.1
    XP_063123762.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022692.2NP_073183.1  ras-related protein Rab-5A

      See identical proteins and their annotated locations for NP_073183.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZS76, A0A8I6A5S3
      Conserved Domains (1) summary
      cd01860
      Location:20182
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      6720057..6749456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084178.2XP_038940106.1  ras-related protein Rab-5A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZS76, A0A8I6A5S3
      Conserved Domains (1) summary
      cd01860
      Location:20182
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    2. XM_039084181.2XP_038940109.1  ras-related protein Rab-5A isoform X3

    3. XM_063267691.1XP_063123761.1  ras-related protein Rab-5A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZS76, A0A8I6A5S3
      Related
      ENSRNOP00000080027.1, ENSRNOT00000108726.2
    4. XM_063267692.1XP_063123762.1  ras-related protein Rab-5A isoform X2

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