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    Xpo1 exportin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85252, updated on 9-Dec-2024

    Summary

    Official Symbol
    Xpo1provided by RGD
    Official Full Name
    exportin 1provided by RGD
    Primary source
    RGD:620517
    See related
    EnsemblRapid:ENSRNOG00000009935 AllianceGenome:RGD:620517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    exp1
    Summary
    Enables DNA-binding transcription factor binding activity and protein domain specific binding activity. Involved in several processes, including cellular response to salt; cellular response to triglyceride; and protein export from nucleus. Predicted to be located in several cellular components, including annulate lamellae; kinetochore; and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 342.2), Spleen (RPKM 314.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Xpo1 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (101434450..101476705)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (97233282..97275536)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (108007421..108049088)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096542 Neighboring gene uncharacterized LOC134481879 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ubiquitin specific peptidase 34 Neighboring gene telomerase RNA component interacting Rnase like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding PubMed 
    enables RNA binding  
    enables nuclear export signal receptor activity  
    enables nuclear export signal receptor activity  
    enables nuclear export signal receptor activity  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables small GTPase binding  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in cellular response to salt PubMed 
    involved_in cellular response to triglyceride PubMed 
    involved_in mRNA export from nucleus  
    involved_in mRNA export from nucleus  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in nucleocytoplasmic transport  
    involved_in protein export from nucleus PubMed 
    involved_in protein export from nucleus  
    acts_upstream_of_or_within protein export from nucleus  
    involved_in protein export from nucleus  
    involved_in protein localization to nucleus  
    acts_upstream_of_or_within protein localization to nucleus  
    involved_in regulation of centrosome duplication  
    acts_upstream_of_or_within regulation of centrosome duplication  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within regulation of protein catabolic process  
    involved_in regulation of protein export from nucleus  
    acts_upstream_of_or_within regulation of protein export from nucleus  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in ribosomal large subunit export from nucleus  
    involved_in ribosomal large subunit export from nucleus  
    involved_in ribosomal large subunit export from nucleus  
    involved_in ribosomal small subunit export from nucleus  
    involved_in ribosomal small subunit export from nucleus  
    involved_in ribosomal small subunit export from nucleus  
    involved_in ribosomal subunit export from nucleus  
    involved_in ribosome biogenesis  
    Items 1 - 25 of 28
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    located_in Cajal body  
    located_in annulate lamellae  
    located_in annulate lamellae  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in kinetochore  
    located_in kinetochore  
    located_in kinetochore  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    exportin-1
    Names
    chromosome region maintenance 1 protein homolog
    exportin 1 (CRM1, yeast, homolog)
    exportin 1, CRM1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053490.2NP_445942.1  exportin-1

      See identical proteins and their annotated locations for NP_445942.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q80U96
      UniProtKB/TrEMBL
      A0A8I6AT26, A6JQ67
      Related
      ENSRNOP00000087052.2, ENSRNOT00000101915.2
      Conserved Domains (1) summary
      COG5101
      Location:151044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      101434450..101476705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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