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    Stag1 STAG1 cohesin complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stag1provided by RGD
    Official Full Name
    STAG1 cohesin complex componentprovided by RGD
    Primary source
    RGD:1310744
    See related
    EnsemblRapid:ENSRNOG00000015389 AllianceGenome:RGD:1310744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in mitotic spindle assembly and sister chromatid cohesion. Predicted to be located in chromatin; mitotic spindle pole; and nuclear lumen. Predicted to be part of cohesin complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 47. Orthologous to human STAG1 (STAG1 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 175.0), Lung (RPKM 150.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stag1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (110057981..110443666)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (101179039..101564684)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (108958099..109342738)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene NCK adaptor protein 1 Neighboring gene solute carrier family 35, member G2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC120094242 Neighboring gene uncharacterized LOC134480221 Neighboring gene ribosomal protein L19, pseudogene 8 Neighboring gene propionyl-CoA carboxylase subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2012 Jun 12. PMID 22628566, Free PMC Article
    2. A potential role for human cohesin in mitotic spindle aster assembly. Gregson HC, et al. J Biol Chem, 2001 Dec 14. PMID 11590136
    3. A unique role of cohesin-SA1 in gene regulation and development. Remeseiro S, et al. EMBO J, 2012 May 2. PMID 22415368, Free PMC Article
    4. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347
    5. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Remeseiro S, et al. Biochim Biophys Acta, 2013 Dec. PMID 23920377, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cohesin subunit SA-1
    Names
    stromal antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108179.2 → NP_001101649.1  cohesin subunit SA-1 isoform 3

      See identical proteins and their annotated locations for NP_001101649.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6G238, A6I2F7, D4A3Q2
      Related
      ENSRNOP00000061907.1, ENSRNOT00000066917.3
      Conserved Domains (2) summary
      pfam08514
      Location:160 → 268
      STAG; STAG domain
      pfam14621
      Location:3 → 58
      RFX5_DNA_bdg; RFX5 DNA-binding domain

    2. NM_001433817.1 → NP_001420746.1  cohesin subunit SA-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K9G6, A0A8I6ADB5

    3. NM_001433818.1 → NP_001420747.1  cohesin subunit SA-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5Y920, A0A8I6ADB5

    4. NM_001433819.1 → NP_001420748.1  cohesin subunit SA-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6ADB5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      110057981..110443666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243631.3 → XP_006243693.1  cohesin subunit SA-1 isoform X1

      Related
      ENSRNOP00000090312.1, ENSRNOT00000115852.2
      Conserved Domains (2) summary
      pfam08514
      Location:160 → 268
      STAG; STAG domain
      pfam14621
      Location:3 → 58
      RFX5_DNA_bdg; RFX5 DNA-binding domain

    2. XM_039081553.2 → XP_038937481.1  cohesin subunit SA-1 isoform X6

      Conserved Domains (2) summary
      pfam08514
      Location:160 → 268
      STAG; STAG domain
      pfam14621
      Location:3 → 58
      RFX5_DNA_bdg; RFX5 DNA-binding domain

    3. XM_039081554.2 → XP_038937482.1  cohesin subunit SA-1 isoform X7

      Conserved Domains (2) summary
      pfam08514
      Location:160 → 268
      STAG; STAG domain
      pfam14621
      Location:3 → 58
      RFX5_DNA_bdg; RFX5 DNA-binding domain

    4. XM_008766528.4 → XP_008764750.1  cohesin subunit SA-1 isoform X1

      See identical proteins and their annotated locations for XP_008764750.1

      UniProtKB/TrEMBL
      A0A0G2K9G6, A0A8I6ADB5
      Conserved Domains (2) summary
      pfam08514
      Location:160 → 268
      STAG; STAG domain
      pfam14621
      Location:3 → 58
      RFX5_DNA_bdg; RFX5 DNA-binding domain

    5. XM_006243632.5 → XP_006243694.1  cohesin subunit SA-1 isoform X1

      See identical proteins and their annotated locations for XP_006243694.1

      UniProtKB/TrEMBL
      A0A0G2K9G6, A0A8I6ADB5
      Related
      ENSRNOP00000074990.1, ENSRNOT00000079618.3
      Conserved Domains (2) summary
      pfam08514
      Location:160 → 268
      STAG; STAG domain
      pfam14621
      Location:3 → 58
      RFX5_DNA_bdg; RFX5 DNA-binding domain

    6. XM_063265596.1 → XP_063121666.1  cohesin subunit SA-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADB5

    7. XM_063265597.1 → XP_063121667.1  cohesin subunit SA-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADB5

    8. XM_039081552.2 → XP_038937480.1  cohesin subunit SA-1 isoform X5

      Conserved Domains (1) summary
      cl26728
      Location:2 → 80
      STAG; STAG domain

    9. XM_039081551.2 → XP_038937479.1  cohesin subunit SA-1 isoform X4

      Conserved Domains (1) summary
      cl26728
      Location:10 → 106
      STAG; STAG domain
    Nucleotide Protein Strain
    Heading Accession and Version

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