Ifnar2 interferon alpha and beta receptor subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ifnar2provided by RGD
Official Full Name: interferon alpha and beta receptor subunit 2provided by RGD
Primary source: RGD:1583177
See related: EnsemblRapid:ENSRNOG00000045668 AllianceGenome:RGD:1583177
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine receptor activity; protein kinase binding activity; and type I interferon binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; cellular response to interferon-beta; and defense response to symbiont. Predicted to act upstream of or within immature T cell proliferation in thymus and regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hepatitis B and immunodeficiency 45. Orthologous to human IFNAR2 (interferon alpha and beta receptor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 163.2), Liver (RPKM 149.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (44099574..44131941)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (30613576..30645958)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (31527790..31559834)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW534327 (e-PCR)
- UniSTS:246564

D11Rat110 (e-PCR), detects polymorphism
- UniSTS:226403

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables type I interferon binding	ISO Inferred from Sequence Orthology more info
enables type I interferon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type I interferon receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in interleukin-22-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon alpha/beta receptor 2

Names: interferon (alpha, beta and omega) receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426990.2 → NP_001413919.1 interferon alpha/beta receptor 2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JLE9, M0R8H7

Related

ENSRNOP00000065773.2, ENSRNOT00000072856.4
NM_001426991.1 → NP_001413920.1 interferon alpha/beta receptor 2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6JLF0