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    Ankrd17 ankyrin repeat domain 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd17provided by RGD
    Official Full Name
    ankyrin repeat domain 17provided by RGD
    Primary source
    RGD:1562348
    See related
    EnsemblRapid:ENSRNOG00000002940 AllianceGenome:RGD:1562348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562348
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of G1/S transition of mitotic cell cycle; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within blood vessel maturation and negative regulation of smooth muscle cell differentiation. Predicted to be located in chromatin and nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human ANKRD17 (ankyrin repeat domain 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 174.3), Thymus (RPKM 170.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd17 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (18007342..18145980)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17723239..17861841)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (19291025..19431521)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene albumin Neighboring gene ribosomal protein L8, pseudogene 4 Neighboring gene uncharacterized LOC134481729 Neighboring gene cytochrome c oxidase assembly factor COX18 Neighboring gene uncharacterized LOC134481731 Neighboring gene uncharacterized LOC134481730

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses. Menning M, et al. FEBS Lett, 2013 Jul 11. PMID 23711367
    2. Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice. Ray D, et al. Biol Reprod, 2012 Apr. PMID 22190705, Free PMC Article
    3. Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. Wang Y, et al. Eur J Immunol, 2012 May. PMID 22328336
    4. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. Deng M, et al. J Biol Chem, 2009 Mar 20. PMID 19150984, Free PMC Article
    5. Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis. Hou SC, et al. FEBS Lett, 2009 Sep 3. PMID 19619540

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 17
    Names
    ankyrin repeat domain protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105999.2 → NP_001099469.1  ankyrin repeat domain-containing protein 17 isoform 3

      See identical proteins and their annotated locations for NP_001099469.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KKG2, A6KKG3, D4A0B4
      Related
      ENSRNOP00000059864.1, ENSRNOT00000068682.4
      Conserved Domains (8) summary
      TIGR02926
      Location:692 → 768
      AhaH; ATP synthase archaeal, H subunit
      smart00248
      Location:993 → 1021
      ANK; ankyrin repeats
      COG0666
      Location:957 → 1183
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:283 → 407
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03938
      Location:681 → 780
      OmpH; Outer membrane protein (OmpH-like)
      pfam12796
      Location:192 → 281
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:290 → 341
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:322 → 351
      ANK; ANK repeat [structural motif]

    2. NM_001401338.1 → NP_001388267.1  ankyrin repeat domain-containing protein 17 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AAR9, A6KKG3
      Related
      ENSRNOP00000086651.1, ENSRNOT00000112709.2

    3. NM_001401339.1 → NP_001388268.1  ankyrin repeat domain-containing protein 17 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AL58, A6KKG3
      Related
      ENSRNOP00000095296.1, ENSRNOT00000119401.2

    4. NM_001401343.1 → NP_001388272.1  ankyrin repeat domain-containing protein 17 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KKG3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      18007342..18145980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272901.1 → XP_063128971.1  ankyrin repeat domain-containing protein 17 isoform X2

      UniProtKB/TrEMBL
      A6KKG3

    2. XM_017599098.3 → XP_017454587.1  ankyrin repeat domain-containing protein 17 isoform X1

      UniProtKB/TrEMBL
      A6KKG3

    3. XM_063272902.1 → XP_063128972.1  ankyrin repeat domain-containing protein 17 isoform X5

      UniProtKB/TrEMBL
      A6KKG3

    4. XM_006250766.5 → XP_006250828.1  ankyrin repeat domain-containing protein 17 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JVW3, A6KKG3
      Related
      ENSRNOP00000069642.1, ENSRNOT00000086542.3
      Conserved Domains (10) summary
      TIGR02926
      Location:692 → 768
      AhaH; ATP synthase archaeal, H subunit
      smart00248
      Location:994 → 1022
      ANK; ankyrin repeats
      COG0195
      Location:1632 → 1679
      NusA; Transcription antitermination factor NusA, contains S1 and KH domains [Transcription]
      COG0666
      Location:958 → 1184
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00105
      Location:1639 → 1701
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:283 → 407
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03938
      Location:681 → 780
      OmpH; Outer membrane protein (OmpH-like)
      pfam12796
      Location:192 → 281
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:290 → 341
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:322 → 351
      ANK; ANK repeat [structural motif]

    5. XM_008770011.4 → XP_008768233.1  ankyrin repeat domain-containing protein 17 isoform X4

      UniProtKB/TrEMBL
      A6KKG3
      Conserved Domains (10) summary
      TIGR02926
      Location:692 → 768
      AhaH; ATP synthase archaeal, H subunit
      smart00248
      Location:993 → 1021
      ANK; ankyrin repeats
      COG0195
      Location:1631 → 1678
      NusA; Transcription antitermination factor NusA, contains S1 and KH domains [Transcription]
      COG0666
      Location:957 → 1183
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00105
      Location:1638 → 1700
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:283 → 407
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03938
      Location:681 → 780
      OmpH; Outer membrane protein (OmpH-like)
      pfam12796
      Location:192 → 281
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:290 → 341
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:322 → 351
      ANK; ANK repeat [structural motif]

    6. XM_063272903.1 → XP_063128973.1  ankyrin repeat domain-containing protein 17 isoform X6

      UniProtKB/TrEMBL
      A6KKG3
    Nucleotide Protein Strain
    Heading Accession and Version

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