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    klg klingon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klgprovided by FlyBase
    Official Full Name
    klingonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017590
    Locus tag
    Dmel_CG6669
    See related
    AllianceGenome:FB:FBgn0017590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6669; CT20712; Dmel\CG6669; h214; Klg; l(3)rN712
    Summary
    Predicted to enable axon guidance receptor activity. Involved in several processes, including behavioral response to ethanol; homophilic cell adhesion via plasma membrane adhesion molecules; and long-term memory. Predicted to be extrinsic component of plasma membrane. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including adult brain; adult head; eye disc; inner photoreceptor cell; and presumptive embryonic/larval system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See klg in Genome Data Viewer
    Location:
    94D3-94D4; 3-77 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22899284..22961731)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18725006..18787453)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43846 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46088 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43655 Neighboring gene Transition protein-like 94D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long-term memory formation in Drosophila requires training-dependent glial transcription. Matsuno M, et al. J Neurosci, 2015 Apr 8. PMID 25855172, Free PMC Article
    2. The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch. Matsuno M, et al. Proc Natl Acad Sci U S A, 2009 Jan 6. PMID 19104051, Free PMC Article
    3. klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron. Butler SJ, et al. Development, 1997 Feb. PMID 9043060
    4. Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila. Noordermeer JN, et al. Neuron, 1998 Nov. PMID 9856456
    5. Transcription factor NF-Y is involved in differentiation of R7 photoreceptor cell in Drosophila. Yoshioka Y, et al. Biol Open, 2012 Jan 15. PMID 23213364, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables axon guidance receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in R7 cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in anesthesia-resistant memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extrinsic component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    klingon
    Names
    CG6669-PA
    klg-PA
    ruslan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22899284..22961731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079730.3 → NP_524454.2  klingon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524454.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91670, Q9VCT4
      Related
      FBpp0083730
      Conserved Domains (5) summary
      cd00096
      Location:118 → 191
      Ig; Immunoglobulin domain
      smart00408
      Location:213 → 273
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:109 → 195
      IG_like; Immunoglobulin like
      cd00063
      Location:392 → 486
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07114
      Location:63 → 124
      DUF1370; Protein of unknown function (DUF1370)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91670 P91670
    Q9VCT4 Q9VCT4

    Gene LinkOut

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