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    Pycr1 pyrroline-5-carboxylate reductase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287877, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pycr1provided by RGD
    Official Full Name
    pyrroline-5-carboxylate reductase 1provided by RGD
    Primary source
    RGD:1307863
    See related
    EnsemblRapid:ENSRNOG00000036682 AllianceGenome:RGD:1307863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in several processes, including L-proline biosynthetic process; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB and autosomal recessive cutis laxa type IIIB. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 41.3), Muscle (RPKM 21.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pycr1 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106416056..106420982, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105917732..105922658, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109817300..109822218, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sirtuin 7 Neighboring gene MAF bZIP transcription factor G Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene NOTUM, palmitoleoyl-protein carboxylesterase Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human pyrroline-5-carboxylate reductase. Meng Z, et al. J Mol Biol, 2006 Jun 23. PMID 16730026
    2. Mutations in PYCR1 cause cutis laxa with progeroid features. Reversade B, et al. Nat Genet, 2009 Sep. PMID 19648921
    3. Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. Merrill MJ, et al. J Biol Chem, 1989 Jun 5. PMID 2722838
    4. Functional specialization in proline biosynthesis of melanoma. De Ingeniis J, et al. PLoS One, 2012. PMID 23024808, Free PMC Article
    5. DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. Yasuda T, et al. Biochem Biophys Res Commun, 2013 Jun 28. PMID 23743200

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proline biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pyrroline-5-carboxylate reductase 1, mitochondrial
    NP_001099327.1
    XP_008766694.1
    XP_008766695.4
    XP_008766696.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105857.3 → NP_001099327.1  pyrroline-5-carboxylate reductase 1, mitochondrial

      See identical proteins and their annotated locations for NP_001099327.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AII4, A0A8I6GJW9, A6HLH3
      Related
      ENSRNOP00000093202.2, ENSRNOT00000110897.2
      Conserved Domains (1) summary
      PLN02688
      Location:1 → 268
      PLN02688; pyrroline-5-carboxylate reductase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106416056..106420982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768472.3 → XP_008766694.1  pyrroline-5-carboxylate reductase 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJW9, D3ZXI0
      Conserved Domains (3) summary
      PLN02688
      Location:27 → 294
      PLN02688; pyrroline-5-carboxylate reductase
      pfam03807
      Location:30 → 124
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:189 → 293
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

    2. XM_008768473.4 → XP_008766695.4  pyrroline-5-carboxylate reductase 1, mitochondrial isoform X1

      Related
      ENSRNOP00000106212.1, ENSRNOT00000122777.1

    3. XM_008768474.2 → XP_008766696.1  pyrroline-5-carboxylate reductase 1, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_008766696.1

      UniProtKB/TrEMBL
      A0A8I6GJW9
      Related
      ENSRNOP00000051832.5, ENSRNOT00000054949.6
      Conserved Domains (1) summary
      PLN02688
      Location:1 → 268
      PLN02688; pyrroline-5-carboxylate reductase
    Nucleotide Protein Strain
    Heading Accession and Version

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