Jak1 Janus kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jak1provided by RGD
Official Full Name: Janus kinase 1provided by RGD
Primary source: RGD:69056
See related: EnsemblRapid:ENSRNOG00000011157 AllianceGenome:RGD:69056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables CCR5 chemokine receptor binding activity and growth hormone receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of homotypic cell-cell adhesion; and positive regulation of sprouting angiogenesis. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytoplasmic side of plasma membrane and cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Biomarker of sciatic neuropathy and transient cerebral ischemia. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 855.0), Spleen (RPKM 452.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (120895606..121004207, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (115780248..115888841, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (119982503..120091452, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Folic acid deficiency exacerbates the inflammatory response of astrocytes after ischemia-reperfusion by enhancing the interaction between IL-6 and JAK-1/pSTAT3.
Title: Folic acid deficiency exacerbates the inflammatory response of astrocytes after ischemia-reperfusion by enhancing the interaction between IL-6 and JAK-1/pSTAT3.
treatment downregulated the expression of JAK1, JAK3 and STAT3, and upregulated cytosolic nuclear factor (NF)kappaB p65 and IkappaB. In conclusion, the results of the present study indicated that curculigoside exhibited significant antiarthritic effects in vivo and in vitro, and the molecular mechanism may be associated with the JAK/STAT/NFkappaB signaling pathway.
Title: Curculigoside exerts significant anti‑arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF‑κB signaling pathway.
Astrocyte expression of GLAST/GFAP was reduced via JAK1/JAK2/STAT3 signaling pathway after exposure to sevoflurane.
Title: Sevoflurane Inhibits Glutamate-Aspartate Transporter and Glial Fibrillary Acidic Protein Expression in Hippocampal Astrocytes of Neonatal Rats Through the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) Pathway.
findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements
Title: Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.
These data demonstrate for the first time that KRV-induced islet destruction is associated with beta cell infection and intra-islet innate immune upregulation early in the disease process.
Title: Kilham Rat Virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis.
Endogenous synthesis of IL-1beta is diminished in nerve tissue in type 1 diabetes and this defect triggers reduced STAT3 signaling and mitochondrial function.
Title: Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons.
Enhanced SOCS1 myocardial signalling is associated with accelerated transition from cardiac hypertrophy to heart failure via gp130/JAK1/STAT3 pathway.
Title: SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway.
LIF-induced JAK1-STAT3 signaling in cardiac myocytes is attenuated by depletion of the anti-oxidant glutathione.
Title: Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes.
Both R507 and R545 are potent novel immunosuppressants with favorable pharmacokinetics and high JAK1/3 selectivity to reduce cardiac allograft rejection.
Title: Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways.
Title: Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Markers

RH128695 (e-PCR)
- UniSTS:212003

AU029082 (e-PCR)
- UniSTS:111716

RH129388 (e-PCR)
- UniSTS:212695

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CCR5 chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-3	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-7	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-10-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-11-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-9-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell-cell junction	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase JAK1

Names: Janus protein tyrosine kinase 1

NP_445918.1

EC 2.7.10.2

XP_006238514.1

EC 2.7.10.2

XP_006238515.1

EC 2.7.10.2

XP_063144581.1

EC 2.7.10.2

XP_063144582.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434540.1 → NP_001421469.1 tyrosine-protein kinase JAK1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AM23, A6JRN2, G3V9W2
NM_001434542.1 → NP_001421471.1 tyrosine-protein kinase JAK1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AM23, A6JRN2, G3V9W2
NM_001434543.1 → NP_001421472.1 tyrosine-protein kinase JAK1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AM23, A6JRN2, G3V9W2
NM_001434544.1 → NP_001421473.1 tyrosine-protein kinase JAK1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AM23, A6JRN2, G3V9W2
NM_053466.1 → NP_445918.1 tyrosine-protein kinase JAK1

See identical proteins and their annotated locations for NP_445918.1

Status: PROVISIONAL

Source sequence(s)

CH473998

UniProtKB/TrEMBL

A0A8I6AM23, A6JRN2, G3V9W2

Related

ENSRNOP00000061649.1, ENSRNOT00000064542.3

Conserved Domains (6) summary

cd05079
Location:869 → 1152

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd10378
Location:426 → 526

SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:582 → 845

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:874 → 1146

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

120895606..121004207 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238452.5 → XP_006238514.1 tyrosine-protein kinase JAK1 isoform X1

Conserved Domains (6) summary

cd05079
Location:869 → 1152

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd10378
Location:426 → 526

SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:582 → 845

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:874 → 1146

Pkinase_Tyr; Protein tyrosine kinase
XM_063288511.1 → XP_063144581.1 tyrosine-protein kinase JAK1 isoform X1
XM_063288512.1 → XP_063144582.1 tyrosine-protein kinase JAK1 isoform X1
XM_006238453.5 → XP_006238515.1 tyrosine-protein kinase JAK1 isoform X1

Conserved Domains (6) summary

cd05079
Location:869 → 1152

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd10378
Location:426 → 526

SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:582 → 845

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:874 → 1146

Pkinase_Tyr; Protein tyrosine kinase